Effect of varicocelectomy on sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M type), LDH, LDH-X, and lipid peroxidation product levels in infertile men with varicocele

To determine the total sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M isoform), lactate dehydrogenase (LDH), LDH-X activities, and lipid peroxidation product (malondialdehyde [MDA]) levels in infertile men with varicocele and to examine the possible effect of varicocelectomy on th...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2005-09, Vol.66 (3), p.610-615
Main Authors: Yeşilli, Çetin, Mungan, Görkem, Seçkiner, Ilker, Akduman, Bülent, Açikgöz, Şerefden, Altan, Korhan, Mungan, Aydin
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Creatine Kinase, MB Form
Gynecology. Andrology. Obstetrics
HSP70 Heat-Shock Proteins
Humans
Infertility, Male
L-Lactate Dehydrogenase
Lipid Peroxidation
Male
Male genital diseases
Malondialdehyde
Medical sciences
Nephrology. Urinary tract diseases
Non tumoral diseases
Varicocele - complications
Varicocele - surgery
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Summary:To determine the total sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M isoform), lactate dehydrogenase (LDH), LDH-X activities, and lipid peroxidation product (malondialdehyde [MDA]) levels in infertile men with varicocele and to examine the possible effect of varicocelectomy on these parameters. Eighty-one men were enrolled in this study. The study population consisted of a control group (n = 25) and a varicocele group (n = 56). Of the 56 patients with varicocele, 26 underwent microsurgical subinguinal varicocelectomy at our institution between July 2002 and July 2003. The standard semen parameters (sperm concentration and motility and Kruger morphology) and total sperm creatine kinase, HspA2, LDH, and LDH-X activities, and MDA levels were assessed in the control and varicocele groups. The differences were compared between the two groups. The same parameters were repeated at 6 months postoperatively in the varicocelectomy group and the preoperative and postoperative results were compared. The sperm concentration was significantly lower in the varicocele group than in the control group ( P = 0.01). The mean sperm HspA2 activities were significantly lower and the LDH activities and MDA levels were significantly greater in the varicocele group than in the control group ( P = 0.005 and P = 0.001, P
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2005.03.078