Involvement of neurotransmitters in urocortin-induced passive avoidance learning in mice

The action of urocortin on one-way passive avoidance learning was tested in mice. Urocortin was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. For study of the roles of various neurotransmitters in mediating the action of uroc...

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Bibliographic Details
Published in:Brain research bulletin 2005-10, Vol.67 (3), p.242-247
Main Authors: Telegdy, G., Tiricz, H., Adamik, A.
Format: Article
Language:English
Subjects:
Acquisition
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - pharmacology
Analysis of Variance
Animals
Atropine - pharmacology
Avoidance Learning - drug effects
Avoidance Learning - physiology
Behavior, Animal
Bicuculline - pharmacology
Corticotropin-Releasing Hormone - pharmacology
Dose-Response Relationship, Drug
Drug Combinations
GABA Antagonists - pharmacology
Hormone Antagonists - pharmacology
Male
Memory
Methysergide - pharmacology
Mice
Muscarinic Antagonists - pharmacology
Neurotransmitter Agents - metabolism
Peptide Fragments - pharmacology
Phenoxybenzamine - pharmacology
Propranolol - pharmacology
Reaction Time - drug effects
Receptors
Retrieval
Serotonin Antagonists - pharmacology
Urocortin
Urocortins
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Summary:The action of urocortin on one-way passive avoidance learning was tested in mice. Urocortin was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. For study of the roles of various neurotransmitters in mediating the action of urocortin on the consolidation of memory, the animals were pretreated with different receptor antagonists. Urocortin facilitated the acquisition, consolidation and also retrieval of the passive avoidance response. The following receptor antagonists blocked the action of urocortin on consolidation: haloperidol, atropine, phenoxybenzamine, bicuculline, the CRF antagonist CRF9–41 and methysergide. Propranolol attenuated, but did not fully block the action of urocortin, while naloxone and nitro- l-arginine were ineffective. The results obtained demonstrate that urocortin is able to improve learning and memory and also retrieval processes in a passive avoidance learning in mice. D2, muscarinic cholinergic, alfa-adrenergic, CRF, serotonergic (5HT 1-2), GABA B receptors are involved in the consolidation of the passive avoidance response.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2005.07.008