Noninvasive Imaging of Cardiac Venous Anatomy With 64-Slice Multi-Slice Computed Tomography and Noninvasive Assessment of Left Ventricular Dyssynchrony by 3-Dimensional Tissue Synchronization Imaging in Patients With Heart Failure Scheduled for Cardiac Resynchronization Therapy

• Published in: The American journal of cardiology 2008-04, Vol.101 (7), p.1023-1029
• Main Authors: Van de Veire, Nico R., MD, PhD, Marsan, Nina Ajmone, MD, Schuijf, Joanne D., MSc, PhD, Bleeker, Gabe B., MD, PhD, Wijffels, Maurits C.E.F., MD, PhD, van Erven, Lieselotte, MD, PhD, Holman, Eduard R., MD, PhD, De Sutter, Johan, MD, PhD, van der Wall, Ernst E., MD, PhD, Schalij, Martin J., MD, PhD, Bax, Jeroen J., MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Cardiac Pacing, Artificial; Cardiology. Vascular system; Cardiovascular; Comparative analysis; Coronary Vessels; Echocardiography; Female; Heart; Heart failure; Heart Failure - diagnosis; Heart Failure - physiopathology; Heart Failure - therapy; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Male; Medical sciences; Middle Aged; Phlebography; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Studies; Systole; Tissues; Tomography; Tomography, X-Ray Computed; Transplants & implants; Ventricular Dysfunction, Left - diagnosis; Ventricular Function, Left
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.11.052

Objectives of this study were to perform a prospective head-to-head comparison between multi-slice computed tomography (MSCT) venography and invasive venography in cardiac resynchronization therapy (CRT) candidates as well as to evaluate the relation between left ventricular (LV) lead position and effect on LV dyssynchrony and immediate response to CRT. Twenty-one consecutive heart failure patients scheduled for CRT implantation were prospectively enrolled to undergo 64-slice MSCT to visualize the venous system, invasive venography during device implantation, and tri-plane tissue synchronization imaging (TSI) before and after implantation. Excellent agreement between MSCT and invasive venography was noted. No significant differences were observed between both techniques regarding vessel diameters. In 12 patients, a match was observed between the area of latest mechanical activation (on TSI) and LV lead position. These patients showed a significant decrease in LV dyssynchrony (43 ± 7 ms to 11 ± 9 ms, p