Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2005-10, Vol.15 (10), p.1632-1636
• Main Authors: Schmid, Ralf S., Jo, Rebecca, Shelton, Stephanie, Kreidberg, Jordan A., Anton, E. S.
• Format: Article
• Language: English
• Subjects: Animals; Blotting, Western; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - physiology; Cell Movement - genetics; Cell Movement - physiology; cerebral cortex; Cerebral Cortex - embryology; Cerebral Cortex - metabolism; Cues; Dab1; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - physiology; Female; Immunoprecipitation; integrin; Integrin alpha3beta1 - genetics; Integrin alpha3beta1 - physiology; Mice; Mutation - physiology; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - physiology; neuronal migration; Pregnancy; Protein Binding; Recombination, Genetic; reelin; Serine Endopeptidases - genetics; Serine Endopeptidases - physiology
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhi041

Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as α3β1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that α3β1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of β1 integrin in a reelin-dependent manner. Thus, α3β1 integrin–reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.