Low Concentrations of Nitric Oxide Exert a Hormetic Effect on Mycobacterium tuberculosis In Vitro

Susceptibilities of 12 clinical Mycobacterium tuberculosis isolates to acidified sodium nitrite (ASN) were compared. The results demonstrate that 8 of the 12 isolates exhibited enhanced survival levels in 1.5 mM ASN compared to levels in medium alone, suggesting that low concentrations of reactive n...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-09, Vol.43 (9), p.4844-4846
Main Authors: Brugmann, William Benjamin, Firmani, Marcia A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colony Count, Microbial
Culture Media
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Medical sciences
Microbial Sensitivity Tests - methods
Microbiology
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - growth & development
Nitric Oxide - pharmacology
Reactive Nitrogen Species - pharmacology
Sodium Nitrite - pharmacology
Tuberculosis, Pulmonary - microbiology
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Summary:Susceptibilities of 12 clinical Mycobacterium tuberculosis isolates to acidified sodium nitrite (ASN) were compared. The results demonstrate that 8 of the 12 isolates exhibited enhanced survival levels in 1.5 mM ASN compared to levels in medium alone, suggesting that low concentrations of reactive nitrogen intermediates have a hormetic effect on M. tuberculosis in vitro.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.9.4844-4846.2005