Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects

Autism is a debilitating neurodevelopmental disorder of early childhood with both genetic and environmental origins. Immune system dysregulation has been hypothesized to be involved in this disorder. We quantified levels of glial fibrillary acidic protein (GFAP) and ss-actin in three areas of the br...

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Bibliographic Details
Published in:Cerebellum (London, England) England), 2005-09, Vol.4 (3), p.206-210
Main Authors: Laurence, J A, Fatemi, S H
Format: Article
Language:English
Subjects:
Actin
Adult
Autism
Autistic Disorder - metabolism
Brain
Cell migration
Cerebellar Cortex - metabolism
Cerebellum
Children
Female
Frontal Lobe - metabolism
Gel electrophoresis
Glial fibrillary acidic protein
Glial Fibrillary Acidic Protein - metabolism
Gliosis
Humans
Immune system
Leukocyte migration
Male
Neurodevelopmental disorders
Parietal Lobe - metabolism
Postmortem Changes
Reference Values
Sodium lauryl sulfate
Western blotting
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Summary:Autism is a debilitating neurodevelopmental disorder of early childhood with both genetic and environmental origins. Immune system dysregulation has been hypothesized to be involved in this disorder. We quantified levels of glial fibrillary acidic protein (GFAP) and ss-actin in three areas of the brain, namely, area 9, area 40 and cerebellum, in age matched autistic and control postmortem specimen using SDS-PAGE and western blotting techniques. Significant elevations in levels of GFAP were observed in all three brain areas in autism. This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes.
ISSN:1473-4222
1473-4230
DOI:10.1080/14734220500208846