Comparison of Fresh Osteochondral Autografts and Allografts: A Canine Model

• Published in: The American journal of sports medicine 2006-07, Vol.34 (7), p.1084-1093
• Main Authors: Glenn, R. Edward, McCarty, Eric C., Potter, Hollis G., Juliao, Saul F., Gordon, Jeffrey D., Spindler, Kurt P.
• Format: Article
• Language: English
• Subjects: Animals; Articular cartilage; Autografts; Biological and medical sciences; Biomechanical Phenomena; Biomechanics; Care and treatment; Cartilage; Cartilage, Articular - diagnostic imaging; Cartilage, Articular - transplantation; Comparative studies; Diseases of the osteoarticular system; Dogs; Female; Femur - diagnostic imaging; Femur - surgery; Femur - transplantation; Health aspects; Histology; Injuries; Knee; Knee injuries; Knee Joint - diagnostic imaging; Knee Joint - surgery; Magnetic Resonance Imaging; Male; Medical sciences; NMR; Nuclear magnetic resonance; Radiography; Skin & tissue grafts; Sports injuries; Sports medicine; Transplantation, Autologous - pathology; Transplantation, Homologous - pathology
• ISSN: 0363-5465; 1552-3365
• DOI: 10.1177/0363546505284846

Background Osteochondral autografts and allografts have been widely used in the treatment of isolated grade IV articular cartilage lesions of the knee. However, the authors are not aware of any study that has prospectively compared fresh osteochondral autografts to fresh allografts with regard to imaging, biomechanical testing, and histology. Hypothesis The imaging, biomechanical properties, and histologic appearance of fresh osteochondral autograft and fresh allo-graft are similar with respect to bony incorporation into host bone, articular cartilage composition, and biomechanical properties. Study Design Controlled laboratory study. Methods Eighteen adult dogs underwent bilateral knee osteochondral graft implantation after creation of an Outerbridge grade IV cartilage defect. One knee received an autograft, and the contralateral knee received a fresh allograft. Nine dogs were sacrificed at 3 months, and 9 dogs were sacrificed at 6 months. Graft analysis included gross examination, radiographs, magnetic resonance imaging, biomechanical testing, and histology. Results Magnetic resonance imaging demonstrated excellent bony incorporation of both autografts and allografts. Biomechanical testing demonstrated no significant difference between autografts versus allografts versus control at 3 or 6 months (P= .36-.91). A post hoc calculation showed 80% power to detect a 30% difference between allograft and control. Histologic examination showed normal cartilage structure for both autografts and allografts. Conclusion Fresh osteochondral autograft and fresh allograft tissues are not statistically different with respect to bony incorporation, articular cartilage composition, or biomechanical properties up to 6 months after implantation. Clinical Relevance The use of fresh allograft tissue to treat osteochondral defects eliminates morbidity associated with harvesting autograft tissue without compromising the results of the surgical procedure.