Haemophilus influenzae type b and pertussis vaccinations in preterm infants

The aim of the study was to evaluate the serological efficacy of Hiberix and Infanrix-DTPa vaccines in preterm infants. The results of the investigation of 61 preterm infants immunized three times (primary vaccination) with Hiberix and Infanrix-DTPa at 6-week intervals are presented. Of the 61 child...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2006-06, Vol.54 (3), p.193-199
Main Authors: Sikora, Janusz Piotr, Chlebna-Sokół, Danuta, Ligenza, Iwona, Sikora, Anna
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Babies
Bordetella pertussis - immunology
Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage
Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology
Gestational Age
Haemophilus influenzae
Haemophilus influenzae type b - immunology
Haemophilus Vaccines
Humans
Immunization
Immunization Schedule
Immunization, Secondary
Infant, Newborn
Infant, Premature - immunology
Premature birth
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - immunology
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Summary:The aim of the study was to evaluate the serological efficacy of Hiberix and Infanrix-DTPa vaccines in preterm infants. The results of the investigation of 61 preterm infants immunized three times (primary vaccination) with Hiberix and Infanrix-DTPa at 6-week intervals are presented. Of the 61 children, 17 were additionally immunized with a booster dose of these vaccines. Postvaccinal response to these immunizations was evaluated by means of an immunoenzymatic method. We observed a significant increase in protective postvaccinal antibody titers against Haemophilus influenzae type b (Hib) and Bordetella pertussis after the primary vaccination compared with the initial antibody levels (p
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-006-0020-4