Clinical features of Behçet's disease in children

Background  Behçet's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown etiology. Objective  The aim of this study was to determine the clinical features and outcome of BD in childhood. Patients and methods  Seventeen patients with BD within a pediatric age group we...

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Bibliographic Details
Published in:International journal of dermatology 2006-06, Vol.45 (6), p.713-716
Main Authors: Borlu, Murat, Ukşal, Ümit, Ferahbaş, Ayten, Evereklioglu, Cem
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Behcet Syndrome - physiopathology
Behcet Syndrome - therapy
Biological and medical sciences
Child
Dermatology
Eye Diseases - drug therapy
Eye Diseases - pathology
Eye Diseases - radiotherapy
Female
Humans
Joint Diseases - pathology
Male
Medical sciences
Mouth Diseases - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scrotum - pathology
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Summary:Background  Behçet's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown etiology. Objective  The aim of this study was to determine the clinical features and outcome of BD in childhood. Patients and methods  Seventeen patients with BD within a pediatric age group were studied since 1997. Results  Boys : girls ratio was 12:5. Familial cases were very frequent (45%). Oral aphthous ulcers were present in all patients (100%), genital aphthous ulcers were present in 16 (94%), ocular lesions in 4 (24%), erythema nodosum in 3 (18%), papulopustules in 8 (47%), joint symptoms in 13 (76%), mild gastrointestinal symptoms in 2 (12%), neurological involvement in 2 (12%), positive pathergy reactions in 13 (76%), and thrombophlebitis in 1 (6%). We used colchicine, systemic corticosteroids, cyclosporine, nonsteroidal anti‐inflammatory drugs, sulfasalazine, and topical agents for the treatment of children with BD. Conclusion  The findings of BD in children are similar as in adults, but the frequency of familial cases is significantly higher.
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2006.02754.x