Self-Assembled Monolayers and Polymer Brushes in Biotechnology:  Current Applications and Future Perspectives

The chemistry and topography of a surface affect biological response and are of fundamental importance, especially when living systems encounter synthetic surfaces. Most biomolecules have immense recognition power (specific binding) and simultaneously have a tendency to physically adsorb onto a soli...

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Bibliographic Details
Published in:Biomacromolecules 2005-09, Vol.6 (5), p.2427-2448
Main Authors: Senaratne, Wageesha, Andruzzi, Luisa, Ober, Christopher K
Format: Article
Language:English
Subjects:
Adsorption
Animals
Applied sciences
Biocompatible Materials - chemistry
Biological and medical sciences
Biological Assay
Biosensing Techniques
Biotechnology
Biotechnology - instrumentation
Biotechnology - methods
Biotechnology - trends
Biotin
Cell Adhesion
Disulfides - chemistry
Electrons
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Humans
Integrins - chemistry
Methods. Procedures. Technologies
Models, Chemical
Organic polymers
Others
Physicochemistry of polymers
Polymers - chemistry
Properties and characterization
Protein Binding
Siloxanes - chemistry
Surface Properties
Various methods and equipments
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Summary:The chemistry and topography of a surface affect biological response and are of fundamental importance, especially when living systems encounter synthetic surfaces. Most biomolecules have immense recognition power (specific binding) and simultaneously have a tendency to physically adsorb onto a solid substrate without specific receptor recognition (nonspecific adsorption). Therefore, to create useful materials for many biotechnology applications, interfaces are required that have both enhanced specific binding and reduced nonspecific binding. Thus, in applications such as sensors, the tailoring of surface chemistry and the use of micro or nanofabrication techniques becomes an important avenue for the production of surfaces with specific binding properties and minimal background interference. Both self-assembled monolayers (SAMs) and polymer brushes have attracted considerable attention as surface-active materials. In this review, we discuss both of these materials with their potential applications in biotechnology. We also summarize lithographic methods for pattern formation using combined top-down and bottom-up approaches and briefly discuss the future of these materials by describing emerging new applications.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm050180a