Autologous transplantation of CD133+ BM-derived stem cells as a therapeutic option for dilatative cardiomyopathy

We report the case of a 58-year-old man with end-stage non-ischemic cardiomyopathy. Baseline transthoracic echocardiography (TTE) and cardiac magnetic resonance (cMRI) revealed a markedly depressed left ventricle systolic function. He underwent autologous CD133+ BM-derived cell transplantation throu...

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Bibliographic Details
Published in:Cytotherapy 2006, Vol.8 (3), p.308-310
Main Authors: Ghodsizad, A, Ruhparwar, A, Marktanner, R, Borowski, A, Mohammad Hasani, M R, Poll, L, Vshivkov, I, Stoldt, V, Voelkel, T, Piechaczek, C, Burchardt, E R, Stockschlaeder, M, Sucker, C, Gams, E, Klein, H M
Format: Report
Language:English
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Summary:We report the case of a 58-year-old man with end-stage non-ischemic cardiomyopathy. Baseline transthoracic echocardiography (TTE) and cardiac magnetic resonance (cMRI) revealed a markedly depressed left ventricle systolic function. He underwent autologous CD133+ BM-derived cell transplantation through a minimally invasive approach. During surgery 19 x 10(6) BM-derived stem cells were injected by the transepimyocardial route. Six months after the operation TTE and cMRI showed a clear improvement in left ventricular contractility.
ISSN:1465-3249