Integrin regulation

Integrin signaling is bidirectional. ‘Inside-out’ signals regulate integrin affinity for adhesive ligands, and ligand-dependent ‘outside-in’ signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins...

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Bibliographic Details
Published in:Current opinion in cell biology 2005-10, Vol.17 (5), p.509-516
Main Authors: Ginsberg, Mark H, Partridge, Anthony, Shattil, Sanford J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Cell Membrane - metabolism
Cell Membrane - physiology
Humans
Integrins - metabolism
Integrins - physiology
Models, Molecular
Molecular Sequence Data
Phosphates - metabolism
Protein Conformation
Protein Kinases - metabolism
Protein Structure, Tertiary
Signal Transduction - physiology
Talin - metabolism
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Summary:Integrin signaling is bidirectional. ‘Inside-out’ signals regulate integrin affinity for adhesive ligands, and ligand-dependent ‘outside-in’ signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2005.08.010