The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells

We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal cont...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2005-09, Vol.90 (9), p.1285-1286
Main Authors: Coenen, S, Pickering, B, Potter, KN, Johnson, PW, Stevenson, FK, Packham, G
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
DNA Transposable Elements - genetics
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins - genetics
Promoter Regions, Genetic - genetics
Proto-Oncogene Proteins c-bcl-2 - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.
ISSN:0390-6078
1592-8721