Fractal Dimension as a Prognostic Factor for Laryngeal Carcinoma

Background: Based on the hypothesis that Fractal Dimension (FD) reflects heterogeneity of tumor tissue, we performed an image analysis study to calculate FD of tissue specimens from patients with laryngeal carcinomas in order to investigate its prognostic value. Materials and Methods: Laryngectomy s...

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Bibliographic Details
Published in:Anticancer research 2005-05, Vol.25 (3B), p.2141-2144
Main Authors: DELIDES, Alexander, PANAYIOTIDES, Ioannis, ALEGAKIS, Athanasios, KYROUDI, Aspasia, BANIS, Constantinos, PAVLAKI, Aikaterini, HELIDONIS, Emmanouel, KITTAS, Christos
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Female
Fractals
Humans
Image Processing, Computer-Assisted - methods
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Prognosis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background: Based on the hypothesis that Fractal Dimension (FD) reflects heterogeneity of tumor tissue, we performed an image analysis study to calculate FD of tissue specimens from patients with laryngeal carcinomas in order to investigate its prognostic value. Materials and Methods: Laryngectomy specimens from 52 patients, who had previously undergone total laryngectomy for squamous cell carcinomas, were examined and their history files reviewed. Ten patients were lost from follow-up. Fractal Analysis software was used to estimate FD of histology sections by the box-counting method. FD of carcinomatous areas was correlated with survival. Results: Patients with a FD lower than the median value of the sample, estimated in sections of carcinomas, had statistically significant higher survival rates. Conclusion: Within the sample of patients studied, FD could be used as a prognostic factor.
ISSN:0250-7005
1791-7530