The effect of the administration of human gamma globulins in a model of BCG infection in mice

The effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration t...

Full description

Saved in:
Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2006-05, Vol.86 (3), p.268-272
Main Authors: Olivares, Nesty, León, Annette, López, Yamilé, Puig, Alina, Cádiz, Armando, Falero, Gustavo, Martínez, Máximo, Sarmiento, Maria E., Fariñas, Mildrey, Infante, Juan F., Sierra, Gustavo, Solís, Rosa L., Acosta, Armando
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animals
Antibodies
BCG
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay - methods
gamma-Globulins - administration & dosage
gamma-Globulins - pharmacokinetics
gamma-Globulins - therapeutic use
Humans
Infection model
Infusions, Parenteral
Lung - immunology
Lung - microbiology
Male
Mice
Mice, Inbred BALB C
Mycobacterium bovis - isolation & purification
Phagocytosis
Saliva - immunology
Tuberculosis
Tuberculosis - immunology
Tuberculosis - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration to mice of human gamma globulins. This treatment of mice inhibited BCG colonization of the lungs ( p < 0.01 ) . A similar inhibitory effect was observed after infection of mice with gamma globulin opsonized BCG organisms ( p < 0.01 ) . These results are relevant for the development of new strategies for the control and treatment of tuberculosis.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2006.01.006