Age-related reorganization of encoding networks directly influences subsequent recognition memory

Functional magnetic resonance imaging was used to link performance-related brain activity during two word encoding tasks to subsequent recognition for those words in young and older adults. There were no significant group differences in performance during encoding, but the young subjects performed b...

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Bibliographic Details
Published in:Brain research. Cognitive brain research 2005-09, Vol.25 (1), p.8-18
Main Authors: Tisserand, Danielle J., McIntosh, Anthony R., van der Veen, Freddy M., Backes, Walter H., Jolles, Jelle
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - physiology
Analysis of Variance
Biological and medical sciences
Brain - blood supply
Brain - physiology
Brain Mapping
Functional magnetic resonance imaging
Fundamental and applied biological sciences. Psychology
Human
Humans
Learning. Memory
Magnetic Resonance Imaging - methods
Medial temporal lobe
Memory
Middle Aged
Nerve Net - blood supply
Nerve Net - physiology
Oxygen - blood
Prefrontal cortex
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time - physiology
Recognition (Psychology) - physiology
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Summary:Functional magnetic resonance imaging was used to link performance-related brain activity during two word encoding tasks to subsequent recognition for those words in young and older adults. There were no significant group differences in performance during encoding, but the young subjects performed better than the older at the recognition task. Performance-related brain networks strongly differed between the two groups. In young subjects, there were two networks associated with performance, one related to encoding (mainly involving premotor and parietal brain regions) and the other to recognition (involving middle frontal, and lateral and medial temporal regions), whereas the network for older subjects (including prefrontal, premotor, lateral and medial temporal regions) was associated both with encoding and recognition. Areas in this network strongly overlapped with those supporting recognition in the young subjects (e.g., medial temporal lobe), suggesting that older subjects may have recruited these areas to maintain performance during encoding. However, this reorganization of brain networks appears to have come at the cost of subsequent recognition.
ISSN:0926-6410
DOI:10.1016/j.cogbrainres.2005.04.016