Differential expression of immune system–related components in midtrimester amniotic fluid from singleton and twin pregnancies

We investigated differences between singleton and twin gestations in immune mediators in midtrimester amniotic fluid. Amniotic fluid from 252 singleton and 46 twin gestations were tested by enzyme-linked immunosorbent assay for interleukin-1β, interleukin-1 receptor antagonist, interleukin-4, tumor...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2005-09, Vol.193 (3), p.942-946
Main Authors: Perni, Sriram C., Kalish, Robin B., Hutson, J. Milton, Karasahin, Emre, Bongiovanni, Ann Marie, Ratushny, Vladimir, Chasen, Stephen T., Witkin, Steven S.
Format: Article
Language:English
Subjects:
Adult
Amniotic fluid
Amniotic Fluid - chemistry
Amniotic Fluid - immunology
Biological and medical sciences
Cytokines
Delivery. Postpartum. Lactation
Diseases of mother, fetus and pregnancy
Disorders
Female
Fetal Membranes, Premature Rupture - immunology
Gynecology. Andrology. Obstetrics
HSP70 Heat-Shock Proteins - analysis
Humans
Inflammation - immunology
Interleukin-1 - analysis
Interleukins - analysis
Leptin - analysis
Macrophage Migration-Inhibitory Factors - analysis
Medical sciences
Midtrimester
Phospholipases A - antagonists & inhibitors
Pregnancy - immunology
Pregnancy Trimester, Second
Pregnancy, Multiple - immunology
Pregnancy. Fetus. Placenta
Preterm premature rupture of membranes
Twins
Uteroglobin - immunology
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Summary:We investigated differences between singleton and twin gestations in immune mediators in midtrimester amniotic fluid. Amniotic fluid from 252 singleton and 46 twin gestations were tested by enzyme-linked immunosorbent assay for interleukin-1β, interleukin-1 receptor antagonist, interleukin-4, tumor necrosis factor-α, nitric oxide, Clara cell protein 16, leptin, and the 70-kDa heat shock protein. A subset of amniotic fluid was also tested for leukemia inhibitory factor, angiogenin, and migration inhibitory factor-related protein 8 and migration inhibitory factor-related protein 14. Data were analyzed by the Mann-Whitney U test and Spearman rank correlation. Median concentrations of interleukin-1β, tumor necrosis factor-α, interleukin-4, Clara cell protein 16, leptin, and angiogenin were increased in amniotic fluid from twins; median levels of the 70-kDa heat shock protein, leukemia inhibitory factor, migration inhibitory factor-related protein 8, and migration inhibitory factor-related protein 14 were highest in amniotic fluid from singletons ( P
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2005.05.081