Interplay between DNA replication and recombination in prokaryotes

The processes of DNA replication and recombination are intertwined at many different levels. In diverse systems, extensive DNA replication can be triggered by genetic recombination, with assembly of a replication complex onto a D-loop recombination intermediate. This and related pathways of replisom...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of microbiology 2005-01, Vol.59 (1), p.43-67
Main Author: KREUZER, Kenneth N
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Bacteriophage T4 - genetics
Biological and medical sciences
Deoxyribonucleic acid
DNA
DNA damage
DNA Repair
DNA Replication
DNA, Bacterial - genetics
Escherichia coli - genetics
Escherichia coli - virology
Fundamental and applied biological sciences. Psychology
Genetic recombination
Genetics
Microbiology
Recombination, Genetic
SOS Response (Genetics)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The processes of DNA replication and recombination are intertwined at many different levels. In diverse systems, extensive DNA replication can be triggered by genetic recombination, with assembly of a replication complex onto a D-loop recombination intermediate. This and related pathways of replisome assembly allow the completion of DNA replication when forks initiated at a conventional replication origin fail before completing replication of the genome. In addition, the repair of double-strand breaks or gaps by homologous recombination requires at least limited DNA replication to replace the missing information. An intricate interplay between replication and recombination is also evident during the termination of bacterial DNA replication and during the induction of the bacterial SOS response to DNA damage.
ISSN:0066-4227
1545-3251
DOI:10.1146/annurev.micro.59.030804.121255