Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

Polyphenolic compounds that showed antibacterial effects and suppressed antibiotic resistance were reviewed. Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effe...

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Bibliographic Details
Published in:Phytochemistry 2005-09, Vol.66 (17), p.2047-2055
Main Authors: Hatano, Tsutomu, Kusuda, Miwako, Inada, Kazutoshi, Ogawa, Tomo-omi, Shiota, Sumiko, Tsuchiya, Tomofusa, Yoshida, Takashi
Format: Article
Language:English
Subjects:
Aloe
animal health
animal pathogenic bacteria
anthraquinones
Antibacterial
antibacterial properties
Antibiotic resistance
Biological and medical sciences
Camellia sinensis (Theaceae)
Chemical constitution
emodin
flavonoids
Flavonoids - pharmacology
Fundamental and applied biological sciences. Psychology
licorice
licoricidin
literature reviews
Metabolism
Metabolism. Physicochemical requirements
methicillin
Methicillin Resistance
MRSA
multiple drug resistance
naphthalene
Phenols - pharmacology
phytochemicals
plant biochemistry
Plant physiology and development
Polyphenol
Polyphenols
Proanthocyanidin
Staphylococcus aureus
Staphylococcus aureus - drug effects
Tannin
tannins
Tannins - pharmacology
Tea
theasinensin
Zanthoxylum piperitum
Zanthoxylum piperitum (Rutaceae)
Zizyphus jujuba var. inermis
Zizyphus jujuba var. inermis (Rhamnaceae)
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Summary:Polyphenolic compounds that showed antibacterial effects and suppressed antibiotic resistance were reviewed. Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(−)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (−)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2005.01.013