Hesr, a Mediator of the Notch Signaling, Functions in Heart and Vessel Development

hesr genes are members of the hairy and enhancer of split-related ( hesr) gene family of basic helix–loop–helix-type transcriptional repressors. hesr genes have been implicated in cardiovascular development as the primary targets of Notch signaling. Functional analysis of hesr2 knockout mice reveale...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2005-07, Vol.15 (5), p.190-194
Main Authors: Kokubo, Hiroki, Miyagawa-Tomita, Sachiko, Johnson, Randy L.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Binding sites
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Coronary Vessels - growth & development
Gene Expression Regulation, Developmental - genetics
Genes
Genetics
Heart
Heart - growth & development
Humans
Ligands
Mutation
Pulmonary arteries
Rodents
Signal Transduction - physiology
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Summary:hesr genes are members of the hairy and enhancer of split-related ( hesr) gene family of basic helix–loop–helix-type transcriptional repressors. hesr genes have been implicated in cardiovascular development as the primary targets of Notch signaling. Functional analysis of hesr2 knockout mice revealed abnormal cardiac hemodynamics, such as atrioventricular valve regurgitation and reduced left ventricular systolic function, caused by hypoplastic AV valves and abnormal cardiomyocytes. Recent evidence demonstrates that hesr1 and hesr2 function redundantly in epithelial-to-mesenchymal transformation during atrioventricular valve formation and maintenance of trabecular cells in the heart ventricles, and in arterial–venous differentiation of blood vessels. This review highlights the many functions of the hesr gene family in heart and vessel development.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2005.05.005