Phenotypic Subtypes in Attention Deficit Hyperactivity Disorder in an Isolated Population

We address the use of two informants in genetic studies and whether familial aggregation is similar for the three phenotypic subtypes of ADHD. Lifetime ADHD was diagnosed in a Dutch isolated population using parents and teachers as informants, creating two subgroups (one or two informants), then fur...

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Bibliographic Details
Published in:European journal of epidemiology 2005, Vol.20 (9), p.789-794
Main Authors: Croes, Esther A., Galta, Rachid El, Houwing-Duistermaat, Jeanine J., Ferdinand, Robert F., León, Sandra López, Rademaker, Tessa A. M., Dekker, Marieke C. J., Oostra, Ben A., Verhulst, Frank, Van Duijn, Cornelia M.
Format: Article
Language:English
Subjects:
Adolescent
Ancestors
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Biological and medical sciences
Child
Child psychiatry
Coefficients
Consanguinity
Disorders
Epidemiology
Female
Genotype & phenotype
Humans
Hyperactivity
Kinship
Male
Medical genetics
Medical sciences
Miscellaneous
Mutation
Netherlands - epidemiology
Parents
Pedigree
Phenotype
Phenotypes
Population genetics
Psychiatric Diseases
Public health. Hygiene
Public health. Hygiene-occupational medicine
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Summary:We address the use of two informants in genetic studies and whether familial aggregation is similar for the three phenotypic subtypes of ADHD. Lifetime ADHD was diagnosed in a Dutch isolated population using parents and teachers as informants, creating two subgroups (one or two informants), then further divided into three phenotypic categories (inattentive, hyperactive/impulsive, combined). Genealogy was collected for all patients. Mean kinship coefficients for the subgroups were calculated. Fifteen of 26 children were linked to a common ancestor within 10 generations. The mean kinship coefficient of patients confirmed by two informants was significantly higher than in patients only scored positive by one informant (p = 0.03). All patients of the inattentive subtype were connected to a common ancestor, which was significantly higher (p = 0.03) than expected. Eighty-one percent of these patients derive of consanguineous marriages, also higher than expected. This means that recessive mutations may be involved in the inattentive subtype. These patients were more closely related than those with the other phenotypes (p
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-005-0366-7