Dual-isotope myocardial SPECT in patients with redefined myocardial infarction

According to the redefinition of myocardial infarction (MI) by the ESC/ACC Committee, patients with unstable angina (UA) without significant elevation of creatine kinase (CK) but with elevation of troponin T should be diagnosed as MI. One hundred and forty-six consecutive patients formerly diagnosed...

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Bibliographic Details
Published in:International journal of cardiology 2005-09, Vol.104 (2), p.204-212
Main Authors: Fukushima, Masato, Seino, Yoshihiko, Kumita, Shin-ichiro, Nakajo, Hidenobu, Cho, Keiichi, Takano, Teruo
Format: Article
Language:English
Subjects:
15- p-Iodophenyl-beta-methylpentadecanoic acid
Aged
Angina, Unstable - blood
Angina, Unstable - diagnostic imaging
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - metabolism
Cardiology. Vascular system
Coronary Angiography
Coronary heart disease
Coronary Stenosis - blood
Coronary Stenosis - diagnostic imaging
Creatine Kinase, MB Form - blood
Diagnosis, Differential
Echocardiography
Electrocardiography
Fatty Acids
Female
Heart
Humans
Iodobenzenes
Male
Medical sciences
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - therapy
Myocardial Revascularization
Radionuclide imaging
Radiopharmaceuticals
Research Design
Retrospective Studies
Thallium Radioisotopes
Tomography, Emission-Computed, Single-Photon - methods
Troponin T
Troponin T - blood
Troponin T - metabolism
Unstable angina
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Summary:According to the redefinition of myocardial infarction (MI) by the ESC/ACC Committee, patients with unstable angina (UA) without significant elevation of creatine kinase (CK) but with elevation of troponin T should be diagnosed as MI. One hundred and forty-six consecutive patients formerly diagnosed as UA, with peak CK levels0.10 ng/ml). Dual SPECT findings were analyzed qualitatively and quantitatively in blinded manner. Forty-seven patients (32%) were redefined as MI and 99 patients (68%) were redefined as UA. On admission, there were small but statistically significant elevations in laboratory parameters such as white blood cell count, C-reactive protein, CK and CK-MB in the redefined MI group compared with the redefined UA group. The proportion of patients with perfusion and metabolic abnormalities was significantly higher in the redefined MI group (Tl defect 36% vs. 4%, odds ratio: 13.5, p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2004.12.015