Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis

We aimed to evaluate antioxidant paraoxonase 1 activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with rheumatoid arthritis. Fifty-seven rheumatoid arthritis patients were included in the study and subgrouped according to disease activity (active, n = 31;...

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Bibliographic Details
Published in:Clinical biochemistry 2005-10, Vol.38 (10), p.951-955
Main Authors: Baskol, Gulden, Demir, Huseyin, Baskol, Mevlut, Kilic, Eser, Ates, Filiz, Kocer, Derya, Muhtaroglu, Sabahattin
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - blood
Aryldialkylphosphatase - blood
Humans
Lipid Peroxidation
Malondialdehyde
Malondialdehyde - blood
Middle Aged
Paraoxonase
Reactive Oxygen Species - blood
Rheumatoid arthritis
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Summary:We aimed to evaluate antioxidant paraoxonase 1 activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with rheumatoid arthritis. Fifty-seven rheumatoid arthritis patients were included in the study and subgrouped according to disease activity (active, n = 31; inactive, n = 26) and compared with healthy controls ( n = 25). Serum paraoxonase 1 activity and MDA levels were measured according to an enzymatic spectrophotometric method. Serum MDA level was higher ( P = 0.001) whereas paraoxonase 1 activity was lower ( P = 0.001) in the patient group than the controls. When active and inactive subgroups were compared with the control group, there was a statistically significant difference between each parameter. Serum MDA levels were significantly higher, while paraoxonase 1 activity was lower in the active and inactive rheumatoid arthritis groups than the control group. But there was not any difference between active and inactive patients with RA. There was a negative correlation between MDA levels and paraoxonase 1 activity. Increased reactive oxygen species levels in rheumatoid arthritis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased MDA levels.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2005.06.010