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T-type calcium channels in differentiation and proliferation
Low-voltage activated, T-type calcium channels (T-channels) are expressed in many developing tissues and may be important in regulating important cellular phenotype transitions leading to cell proliferation, differentiation, growth and death. The purpose of this review is to relate and delineate the...
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| Published in: | Cell calcium (Edinburgh) 2006-08, Vol.40 (2), p.135-146 |
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| Main Authors: | , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c385t-200d786ab5adfef79c8f8c352de6f3b618c65aa9aa4bed563f54bfd31e4575a03 |
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| container_end_page | 146 |
| container_issue | 2 |
| container_start_page | 135 |
| container_title | Cell calcium (Edinburgh) |
| container_volume | 40 |
| creator | Lory, Philippe Bidaud, Isabelle Chemin, Jean |
| description | Low-voltage activated, T-type calcium channels (T-channels) are expressed in many developing tissues and may be important in regulating important cellular phenotype transitions leading to cell proliferation, differentiation, growth and death. The purpose of this review is to relate and delineate the current data on the involvement of T-channels in differentiation and proliferation. Owing to the recent cloning of the Ca
V3.1, Ca
V3.2 and Ca
V3.3 subunits coding for T-channels, classical electrophysiological and pharmacological approaches are now being supported by molecular investigations. As T-channels are expressed in early development as well as re-expressed in several disease-states, our goal is to provide a comprehensive scheme of the current hypothesis connecting the activity of T-channels to cell differentiation and proliferation, as well as the potential physiological and pathophysiological implications. |
| doi_str_mv | 10.1016/j.ceca.2006.04.017 |
| format | article |
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V3.1, Ca
V3.2 and Ca
V3.3 subunits coding for T-channels, classical electrophysiological and pharmacological approaches are now being supported by molecular investigations. As T-channels are expressed in early development as well as re-expressed in several disease-states, our goal is to provide a comprehensive scheme of the current hypothesis connecting the activity of T-channels to cell differentiation and proliferation, as well as the potential physiological and pathophysiological implications.</description><identifier>ISSN: 0143-4160</identifier><identifier>EISSN: 1532-1991</identifier><identifier>DOI: 10.1016/j.ceca.2006.04.017</identifier><identifier>PMID: 16797068</identifier><language>eng</language><publisher>Netherlands: Elsevier India Pvt Ltd</publisher><subject>Animals ; Calcium Channels, T-Type - metabolism ; Cardiac myocyte ; Cell Differentiation ; Cell Proliferation ; Development ; Differentiation ; Gene Expression Regulation, Developmental ; Growth ; Humans ; Neuron ; Proliferation ; Skeletal muscle ; T-type calcium channels ; Transcription, Genetic</subject><ispartof>Cell calcium (Edinburgh), 2006-08, Vol.40 (2), p.135-146</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-200d786ab5adfef79c8f8c352de6f3b618c65aa9aa4bed563f54bfd31e4575a03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16797068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lory, Philippe</creatorcontrib><creatorcontrib>Bidaud, Isabelle</creatorcontrib><creatorcontrib>Chemin, Jean</creatorcontrib><title>T-type calcium channels in differentiation and proliferation</title><title>Cell calcium (Edinburgh)</title><addtitle>Cell Calcium</addtitle><description>Low-voltage activated, T-type calcium channels (T-channels) are expressed in many developing tissues and may be important in regulating important cellular phenotype transitions leading to cell proliferation, differentiation, growth and death. The purpose of this review is to relate and delineate the current data on the involvement of T-channels in differentiation and proliferation. Owing to the recent cloning of the Ca
V3.1, Ca
V3.2 and Ca
V3.3 subunits coding for T-channels, classical electrophysiological and pharmacological approaches are now being supported by molecular investigations. As T-channels are expressed in early development as well as re-expressed in several disease-states, our goal is to provide a comprehensive scheme of the current hypothesis connecting the activity of T-channels to cell differentiation and proliferation, as well as the potential physiological and pathophysiological implications.</description><subject>Animals</subject><subject>Calcium Channels, T-Type - metabolism</subject><subject>Cardiac myocyte</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Development</subject><subject>Differentiation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Growth</subject><subject>Humans</subject><subject>Neuron</subject><subject>Proliferation</subject><subject>Skeletal muscle</subject><subject>T-type calcium channels</subject><subject>Transcription, Genetic</subject><issn>0143-4160</issn><issn>1532-1991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMo7rr6BzxIT95ak6ZJGtiLiF-w4GU9hzSZYJY2XZOusP_e1l3wpqeB4XnfGR6ErgkuCCb8blMYMLooMeYFrgpMxAmaE0bLnEhJTtEck4rmFeF4hi5S2mCMJRXkHM0IF1JgXs_Rcp0P-y1kRrfG77rMfOgQoE2ZD5n1zkGEMHg9-D5kOthsG_vWj9ufzSU6c7pNcHWcC_T-9Lh-eMlXb8-vD_er3NCaDfn4oBU11w3T1oET0tSuNpSVFrijDSe14UxrqXXVgGWcOlY1zlICFRNMY7pAt4fe8frnDtKgOp8MtK0O0O-S4jWTXJbiX5CIkhEqJrA8gCb2KUVwaht9p-NeEawmuWqjJrlqkqtwpUa5Y-jm2L5rOrC_kaPNEVgegFEgfHmIKhkPwYD1EcygbO__6v8Gb0mLMQ</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Lory, Philippe</creator><creator>Bidaud, Isabelle</creator><creator>Chemin, Jean</creator><general>Elsevier India Pvt Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>T-type calcium channels in differentiation and proliferation</title><author>Lory, Philippe ; Bidaud, Isabelle ; Chemin, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-200d786ab5adfef79c8f8c352de6f3b618c65aa9aa4bed563f54bfd31e4575a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Calcium Channels, T-Type - metabolism</topic><topic>Cardiac myocyte</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Development</topic><topic>Differentiation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Growth</topic><topic>Humans</topic><topic>Neuron</topic><topic>Proliferation</topic><topic>Skeletal muscle</topic><topic>T-type calcium channels</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lory, Philippe</creatorcontrib><creatorcontrib>Bidaud, Isabelle</creatorcontrib><creatorcontrib>Chemin, Jean</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell calcium (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lory, Philippe</au><au>Bidaud, Isabelle</au><au>Chemin, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-type calcium channels in differentiation and proliferation</atitle><jtitle>Cell calcium (Edinburgh)</jtitle><addtitle>Cell Calcium</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>40</volume><issue>2</issue><spage>135</spage><epage>146</epage><pages>135-146</pages><issn>0143-4160</issn><eissn>1532-1991</eissn><abstract>Low-voltage activated, T-type calcium channels (T-channels) are expressed in many developing tissues and may be important in regulating important cellular phenotype transitions leading to cell proliferation, differentiation, growth and death. The purpose of this review is to relate and delineate the current data on the involvement of T-channels in differentiation and proliferation. Owing to the recent cloning of the Ca
V3.1, Ca
V3.2 and Ca
V3.3 subunits coding for T-channels, classical electrophysiological and pharmacological approaches are now being supported by molecular investigations. As T-channels are expressed in early development as well as re-expressed in several disease-states, our goal is to provide a comprehensive scheme of the current hypothesis connecting the activity of T-channels to cell differentiation and proliferation, as well as the potential physiological and pathophysiological implications.</abstract><cop>Netherlands</cop><pub>Elsevier India Pvt Ltd</pub><pmid>16797068</pmid><doi>10.1016/j.ceca.2006.04.017</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0143-4160 |
| ispartof | Cell calcium (Edinburgh), 2006-08, Vol.40 (2), p.135-146 |
| issn | 0143-4160 1532-1991 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Calcium Channels, T-Type - metabolism Cardiac myocyte Cell Differentiation Cell Proliferation Development Differentiation Gene Expression Regulation, Developmental Growth Humans Neuron Proliferation Skeletal muscle T-type calcium channels Transcription, Genetic |
| title | T-type calcium channels in differentiation and proliferation |
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