Screening of serologically negative plasma pools for hepatitis C virus by nucleic acid amplification testing in Croatia, 2001–2003

A residual risk of HCV infection by different blood products exists due to blood donations collected during the serological window period in the early stages of infection. The aim of this study is nucleic acid amplification technique (NAT)-based screening of the anti-HCV negative plasma pools obtain...

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Bibliographic Details
Published in:Transfusion and apheresis science 2005-10, Vol.33 (2), p.175-179
Main Authors: Forčić, Dubravko, Zgorelec, Renata, Košutić-Gulija, Tanja, Ivančić, Jelena, Baričević, Marijana, Lupret, Ljerka, Mažuran, Renata
Format: Article
Language:English
Subjects:
Blood Donors
Capsid Proteins - blood
Capsid Proteins - genetics
Croatia
Female
HCV RNA
Health technology assessment
Hepacivirus - genetics
Hepatitis C - blood
Hepatitis C - epidemiology
Hepatitis C - genetics
Hepatitis C Antibodies - blood
Hepatitis C virus
Humans
Male
Mass Screening - methods
NAT
Plasma pools
Predictive Value of Tests
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Viral - blood
RNA, Viral - genetics
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Summary:A residual risk of HCV infection by different blood products exists due to blood donations collected during the serological window period in the early stages of infection. The aim of this study is nucleic acid amplification technique (NAT)-based screening of the anti-HCV negative plasma pools obtained from various Croatian transfusion centres between 2001 and 2003 for HCV RNA. During this period 2647 anti-HCV negative plasma pools were tested by NAT and 12 (0.45%) HCV RNA positive pools were detected. In comparison to the results of our previous study [Forčić D, Zgorelec R, Branović K, Košutić-Gulija T, Šantak M, Mažuran R. Incidence of hepatitis C virus RNA in anti-HCV negative plasma pools in Croatia. Transfus Apher Sci 2001;24:269–78], a remarkable decrease in the number of positive plasma pools (from 2.1% to 0.45%) was demonstrated.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2005.07.003