Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2006-09, Vol.6 (5), p.361-367
Main Authors: Taype, C.A., Castro, J.C., Accinelli, R.A., Herrera-Velit, P., Shaw, M.A., Espinoza, J.R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allelic association
Cation Transport Proteins - genetics
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Miliary
Peru - epidemiology
Pleural
Polymorphism, Genetic
Pulmonary
SLC11A1
Tuberculosis
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - genetics
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Summary:Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB ( P = 0.02 and 0.03 respectively). INT4–D543N–3′UTR haplotypes showed an association with pulmonary TB ( P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form ( P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2006.01.002