Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia

Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele fr...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2006-08, Vol.30 (6), p.1136-1138
Main Authors: Vaquero Lorenzo, Concepcion, Baca-Garcia, Enrique, Diaz-Hernandez, Montserrat, Botillo-Martin, Carlota, Perez-Rodriguez, M. Mercedes, Fernandez-Ramos, Carolina, Saiz-Gonzalez, M. Dolores, Quintero-Gutierrez, Francisco J., Saiz-Ruiz, Jeronimo, Fernandez Piqueras, Jose, Gonzalez de Rivera, Jose Luis, de Leon, Jose
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Alleles
Biological and medical sciences
Case-Control Studies
DNA - genetics
Female
Gene Dosage
Genotype
Humans
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptor, Serotonin, 5-HT2A - genetics
Reverse Transcriptase Polymerase Chain Reaction
Risk
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Schizophrenia - metabolism
Serotonin 5-HT2A receptor
Spain - epidemiology
T102C polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2006.04.027