Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein

To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeable Haemophilus influenzae (NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were ex...

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Bibliographic Details
Published in:Vaccine 2006-07, Vol.24 (31), p.5896-5903
Main Authors: Kurita, Shin-ichi, Koyama, Jun, Onizuka, Shozaburo, Motomura, Kazushi, Watanabe, Hiroshi, Watanabe, Kiwao, Senba, Masachika, Apicella, Michael A., Murphy, Timothy F., Yoneyama, Horoyuki, Matsushima, Kouji, Nagatake, Tsuyoshi, Oishi, Kazunori
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Applied microbiology
Bacterial Outer Membrane Proteins - immunology
Bacteriology
Biological and medical sciences
Cell Movement - immunology
Cells, Cultured
Dendritic cell
Dendritic Cells - immunology
Fundamental and applied biological sciences. Psychology
Haemophilus Infections - immunology
Haemophilus Infections - prevention & control
Haemophilus influenzae
Haemophilus influenzae - immunology
Haemophilus Vaccines - immunology
Humans
Lung - cytology
Lung - immunology
Mice
Microbiology
Miscellaneous
Nontypeable Haemophilus influenzae
P6 protein
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeable Haemophilus influenzae (NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were examined after repeated airway challenges with outer membrane protein (OMP) at 1-week intervals in mice. Although the migration of mature DC into the pulmonary LN is attenuated after repeated airway challenge with OMP, the in vitro P6-specific T cell proliferation in the cultured pulmonary LN cells was enhanced and was subsequently linked to the development of P6-specific IgA production and the development of protective immunity in the airway of mice.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.04.041