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Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein
To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeable Haemophilus influenzae (NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were ex...
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| Published in: | Vaccine 2006-07, Vol.24 (31), p.5896-5903 |
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| Main Authors: | , , , , , , , , , , , , |
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| container_end_page | 5903 |
| container_issue | 31 |
| container_start_page | 5896 |
| container_title | Vaccine |
| container_volume | 24 |
| creator | Kurita, Shin-ichi Koyama, Jun Onizuka, Shozaburo Motomura, Kazushi Watanabe, Hiroshi Watanabe, Kiwao Senba, Masachika Apicella, Michael A. Murphy, Timothy F. Yoneyama, Horoyuki Matsushima, Kouji Nagatake, Tsuyoshi Oishi, Kazunori |
| description | To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeable
Haemophilus influenzae (NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were examined after repeated airway challenges with outer membrane protein (OMP) at 1-week intervals in mice. Although the migration of mature DC into the pulmonary LN is attenuated after repeated airway challenge with OMP, the in vitro P6-specific T cell proliferation in the cultured pulmonary LN cells was enhanced and was subsequently linked to the development of P6-specific IgA production and the development of protective immunity in the airway of mice. |
| doi_str_mv | 10.1016/j.vaccine.2006.04.041 |
| format | article |
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Haemophilus influenzae (NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were examined after repeated airway challenges with outer membrane protein (OMP) at 1-week intervals in mice. Although the migration of mature DC into the pulmonary LN is attenuated after repeated airway challenge with OMP, the in vitro P6-specific T cell proliferation in the cultured pulmonary LN cells was enhanced and was subsequently linked to the development of P6-specific IgA production and the development of protective immunity in the airway of mice.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16797801</pmid><doi>10.1016/j.vaccine.2006.04.041</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vaccine, 2006-07, Vol.24 (31), p.5896-5903 |
| issn | 0264-410X 1873-2518 |
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| source | ScienceDirect Journals |
| subjects | Administration, Inhalation Animals Applied microbiology Bacterial Outer Membrane Proteins - immunology Bacteriology Biological and medical sciences Cell Movement - immunology Cells, Cultured Dendritic cell Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Haemophilus Infections - immunology Haemophilus Infections - prevention & control Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus Vaccines - immunology Humans Lung - cytology Lung - immunology Mice Microbiology Miscellaneous Nontypeable Haemophilus influenzae P6 protein Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein |
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