Thermogelling emulsions for vascular embolization and sustained release of drugs

Thermogelling emulsion system was developed to function as an embolic agent and sustained release system. PEG‐PLGA‐PEG triblock copolymer was synthesized, and blended with oily phase (Lipiodol®) to constitute the thermogelling emulsions. Because the polymer‐rich aqueous phase dramatically increases...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2005-10, Vol.75B (1), p.185-192
Main Authors: Kan, Pei, Lin, Xi-Zhang, Hsieh, Ming-Fa, Chang, Ken-Yuen
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - drug effects
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
embolization
Embolization, Therapeutic - instrumentation
Embolization, Therapeutic - methods
emulsion
Emulsions - chemistry
Hydrogels - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
paclitaxel
Paclitaxel - administration & dosage
Paclitaxel - chemistry
Paclitaxel - pharmacology
Polymers - chemistry
Rabbits
sustained release
Temperature
thermoresponsive
Viscosity
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Summary:Thermogelling emulsion system was developed to function as an embolic agent and sustained release system. PEG‐PLGA‐PEG triblock copolymer was synthesized, and blended with oily phase (Lipiodol®) to constitute the thermogelling emulsions. Because the polymer‐rich aqueous phase dramatically increases viscosity in response to temperature change, especially within the range between 20 and 30°C, the emulsions produce a stop‐flowing gel with oil droplets entrapped. Thereafter, paclitaxels were released from the oily reservoir of gelled emulsions in a controlled manner. Reduced burst effect and steady drug release with near zero‐order release kinetics were observed. Human umbilical vein endothelial cells (HUVEC) were collected from fresh umbilical cords for in vitro antiangiogenesis test. It demonstrated that the sustained release of paclitaxel from emulsions inhibited growth of HUVEC and that the IC50, calculated according to release rate, was consistent with that obtained from free drug study. In addition, the emulsions forming a depot in situ inside the injection site of the blood vessel in rabbit ear obstructed the blood flow, and being monitored under X‐ray angiography. Taken together, this study proved the feasibility of the thermogelling emulsions for vascular embolization and sustained drug release. The results presented a potential system for arterial transcatheter embolization on hepatocellular carcinoma combined with antiangiogeneic treatment. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2005
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.30286