Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants approximately 10(5) mol(-1) dm(3); the glycosylated arylacetylide complexes exhibit emission at lambda(max) approximately 620 nm in water and are up to approximately 100-times...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-10 (37), p.4675-4677
Main Authors: Ma, Dik-Lung, Shum, Tina Yuen-Ting, Zhang, Fuyi, Che, Chi-Ming, Yang, Mengsu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Chemical Phenomena
Chemistry, Physical
Cisplatin - pharmacology
DNA - chemistry
DNA - metabolism
Drug Screening Assays, Antitumor
Electrophoresis, Polyacrylamide Gel
Electrophoretic Mobility Shift Assay
Glycosylation
Humans
Ligands
Luminescence
Magnetic Resonance Spectroscopy
Molecular Conformation
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - pharmacology
Photochemistry
Pyridines - chemical synthesis
Restriction Mapping
Solubility
Spectrophotometry, Ultraviolet
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants approximately 10(5) mol(-1) dm(3); the glycosylated arylacetylide complexes exhibit emission at lambda(max) approximately 620 nm in water and are up to approximately 100-times higher in potency than the clinical cisplatin drug in killing cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/b507114c