Loading…
Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone
Parents of children with opsoclonus-myoclonus syndrome (OMS) frequently describe poor sleep and rage attacks. We hypothesized that these manifestations are related and could result from underlying monoaminergic dysfunction. We clinically characterized the sleep and behavioral characteristics of 51 y...
Saved in:
| Published in: | The Journal of pediatrics 2005-09, Vol.147 (3), p.372-378 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93 |
| container_end_page | 378 |
| container_issue | 3 |
| container_start_page | 372 |
| container_title | The Journal of pediatrics |
| container_volume | 147 |
| creator | Pranzatelli, Michael R. Tate, Elizabeth D. Dukart, William S. Flint, Mary Jo Hoffman, Michael T. Oksa, Amy E. |
| description | Parents of children with opsoclonus-myoclonus syndrome (OMS) frequently describe poor sleep and rage attacks. We hypothesized that these manifestations are related and could result from underlying monoaminergic dysfunction.
We clinically characterized the sleep and behavioral characteristics of 51 young children with OMS; 19 of those with the most disruptive sleep patterns were treated with trazodone, a soporific serotonergic agent.
Sleep disturbances, including prolonged sleep latency, fragmented sleep, reduced quantity of sleep, snoring, and nonrestorative sleep, were reported in 32 children, and frequent rage attacks were reported in 25. In 59% of the poor sleepers, parents felt that the problem was severe enough to warrant treatment. Children sleeping |
| doi_str_mv | 10.1016/j.jpeds.2005.05.016 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68607574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347605004166</els_id><sourcerecordid>68607574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93</originalsourceid><addsrcrecordid>eNp9kMFq3DAQhkVpaLZpnyBQdGlu3oxkW7ILPYSkTQMJgSS99CK00jho67UcjV3YPn28WUNugYGZw_cPMx9jxwKWAoQ6XS_XPXpaSoByuSuh3rGFgFpnqsrz92wBIGWWF1odso9EawCoC4AP7FAoUUmlqwX7c98i9vwi0DCmle0cctt5fmcfkZ8Ng3V_iYeO3_YUXRu7kbKb7Tzx-23nU9zgN36H1MeOkA-RPyT7P_rY4Sd20NiW8PPcj9jvnz8ezn9l17eXV-dn15krcjlkVgidW61kUcL0V1l7V1e-KIQrwfkGRSHqVW1rACEbARWilFZVTaOcKpWv8yN2st_bp_g0Ig1mE8hh29oO40hGVQp0qYsJzPegS5EoYWP6FDY2bY0As1Nq1uZFqdkpNbsSakp9mdePqw3618zscAK-zoAlZ9smTRYDvXJaShC6nLjvew4nGf8CJkMu4GTch4RuMD6GNw95BvqylSU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68607574</pqid></control><display><type>article</type><title>Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone</title><source>ScienceDirect Journals</source><creator>Pranzatelli, Michael R. ; Tate, Elizabeth D. ; Dukart, William S. ; Flint, Mary Jo ; Hoffman, Michael T. ; Oksa, Amy E.</creator><creatorcontrib>Pranzatelli, Michael R. ; Tate, Elizabeth D. ; Dukart, William S. ; Flint, Mary Jo ; Hoffman, Michael T. ; Oksa, Amy E.</creatorcontrib><description>Parents of children with opsoclonus-myoclonus syndrome (OMS) frequently describe poor sleep and rage attacks. We hypothesized that these manifestations are related and could result from underlying monoaminergic dysfunction.
We clinically characterized the sleep and behavioral characteristics of 51 young children with OMS; 19 of those with the most disruptive sleep patterns were treated with trazodone, a soporific serotonergic agent.
Sleep disturbances, including prolonged sleep latency, fragmented sleep, reduced quantity of sleep, snoring, and nonrestorative sleep, were reported in 32 children, and frequent rage attacks were reported in 25. In 59% of the poor sleepers, parents felt that the problem was severe enough to warrant treatment. Children sleeping <10 hours/night had a higher rage frequency than those who slept more. Of the children who required trazodone, 84% were receiving corticosteroids or adrenocorticotropic hormone (corticotrophin), compared with 37% in the subgroup with normal sleep. Trazodone (3.0 ± 0.4 mg/kg/day) improved sleep and behavior in 95% of the children, significantly increasing total sleep time by 72%, decreasing the number of awakenings by 76%, and reducing rage attacks by 33%.
Children with OMS exhibited multiple types of sleep disturbances, which contributed to rage attacks. Trazodone was effective in improving sleep and decreasing rage attacks and was well tolerated, even in toddlers.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2005.05.016</identifier><identifier>PMID: 16182678</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Affective Symptoms - drug therapy ; Affective Symptoms - etiology ; Biological and medical sciences ; Child ; Child, Preschool ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Dose-Response Relationship, Drug ; Female ; General aspects ; Humans ; Infant ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Oculomotor disorders ; Ophthalmology ; Paraneoplastic Syndromes, Nervous System - psychology ; Rage ; Retrospective Studies ; Serotonin Uptake Inhibitors - therapeutic use ; Sleep Wake Disorders - drug therapy ; Sleep Wake Disorders - etiology ; Trazodone - administration & dosage ; Trazodone - therapeutic use ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2005-09, Vol.147 (3), p.372-378</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93</citedby><cites>FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17220175$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16182678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pranzatelli, Michael R.</creatorcontrib><creatorcontrib>Tate, Elizabeth D.</creatorcontrib><creatorcontrib>Dukart, William S.</creatorcontrib><creatorcontrib>Flint, Mary Jo</creatorcontrib><creatorcontrib>Hoffman, Michael T.</creatorcontrib><creatorcontrib>Oksa, Amy E.</creatorcontrib><title>Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Parents of children with opsoclonus-myoclonus syndrome (OMS) frequently describe poor sleep and rage attacks. We hypothesized that these manifestations are related and could result from underlying monoaminergic dysfunction.
We clinically characterized the sleep and behavioral characteristics of 51 young children with OMS; 19 of those with the most disruptive sleep patterns were treated with trazodone, a soporific serotonergic agent.
Sleep disturbances, including prolonged sleep latency, fragmented sleep, reduced quantity of sleep, snoring, and nonrestorative sleep, were reported in 32 children, and frequent rage attacks were reported in 25. In 59% of the poor sleepers, parents felt that the problem was severe enough to warrant treatment. Children sleeping <10 hours/night had a higher rage frequency than those who slept more. Of the children who required trazodone, 84% were receiving corticosteroids or adrenocorticotropic hormone (corticotrophin), compared with 37% in the subgroup with normal sleep. Trazodone (3.0 ± 0.4 mg/kg/day) improved sleep and behavior in 95% of the children, significantly increasing total sleep time by 72%, decreasing the number of awakenings by 76%, and reducing rage attacks by 33%.
Children with OMS exhibited multiple types of sleep disturbances, which contributed to rage attacks. Trazodone was effective in improving sleep and decreasing rage attacks and was well tolerated, even in toddlers.</description><subject>Adolescent</subject><subject>Affective Symptoms - drug therapy</subject><subject>Affective Symptoms - etiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Oculomotor disorders</subject><subject>Ophthalmology</subject><subject>Paraneoplastic Syndromes, Nervous System - psychology</subject><subject>Rage</subject><subject>Retrospective Studies</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Sleep Wake Disorders - drug therapy</subject><subject>Sleep Wake Disorders - etiology</subject><subject>Trazodone - administration & dosage</subject><subject>Trazodone - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAQhkVpaLZpnyBQdGlu3oxkW7ILPYSkTQMJgSS99CK00jho67UcjV3YPn28WUNugYGZw_cPMx9jxwKWAoQ6XS_XPXpaSoByuSuh3rGFgFpnqsrz92wBIGWWF1odso9EawCoC4AP7FAoUUmlqwX7c98i9vwi0DCmle0cctt5fmcfkZ8Ng3V_iYeO3_YUXRu7kbKb7Tzx-23nU9zgN36H1MeOkA-RPyT7P_rY4Sd20NiW8PPcj9jvnz8ezn9l17eXV-dn15krcjlkVgidW61kUcL0V1l7V1e-KIQrwfkGRSHqVW1rACEbARWilFZVTaOcKpWv8yN2st_bp_g0Ig1mE8hh29oO40hGVQp0qYsJzPegS5EoYWP6FDY2bY0As1Nq1uZFqdkpNbsSakp9mdePqw3618zscAK-zoAlZ9smTRYDvXJaShC6nLjvew4nGf8CJkMu4GTch4RuMD6GNw95BvqylSU</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Pranzatelli, Michael R.</creator><creator>Tate, Elizabeth D.</creator><creator>Dukart, William S.</creator><creator>Flint, Mary Jo</creator><creator>Hoffman, Michael T.</creator><creator>Oksa, Amy E.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone</title><author>Pranzatelli, Michael R. ; Tate, Elizabeth D. ; Dukart, William S. ; Flint, Mary Jo ; Hoffman, Michael T. ; Oksa, Amy E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Affective Symptoms - drug therapy</topic><topic>Affective Symptoms - etiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Oculomotor disorders</topic><topic>Ophthalmology</topic><topic>Paraneoplastic Syndromes, Nervous System - psychology</topic><topic>Rage</topic><topic>Retrospective Studies</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Sleep Wake Disorders - drug therapy</topic><topic>Sleep Wake Disorders - etiology</topic><topic>Trazodone - administration & dosage</topic><topic>Trazodone - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pranzatelli, Michael R.</creatorcontrib><creatorcontrib>Tate, Elizabeth D.</creatorcontrib><creatorcontrib>Dukart, William S.</creatorcontrib><creatorcontrib>Flint, Mary Jo</creatorcontrib><creatorcontrib>Hoffman, Michael T.</creatorcontrib><creatorcontrib>Oksa, Amy E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pranzatelli, Michael R.</au><au>Tate, Elizabeth D.</au><au>Dukart, William S.</au><au>Flint, Mary Jo</au><au>Hoffman, Michael T.</au><au>Oksa, Amy E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>147</volume><issue>3</issue><spage>372</spage><epage>378</epage><pages>372-378</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Parents of children with opsoclonus-myoclonus syndrome (OMS) frequently describe poor sleep and rage attacks. We hypothesized that these manifestations are related and could result from underlying monoaminergic dysfunction.
We clinically characterized the sleep and behavioral characteristics of 51 young children with OMS; 19 of those with the most disruptive sleep patterns were treated with trazodone, a soporific serotonergic agent.
Sleep disturbances, including prolonged sleep latency, fragmented sleep, reduced quantity of sleep, snoring, and nonrestorative sleep, were reported in 32 children, and frequent rage attacks were reported in 25. In 59% of the poor sleepers, parents felt that the problem was severe enough to warrant treatment. Children sleeping <10 hours/night had a higher rage frequency than those who slept more. Of the children who required trazodone, 84% were receiving corticosteroids or adrenocorticotropic hormone (corticotrophin), compared with 37% in the subgroup with normal sleep. Trazodone (3.0 ± 0.4 mg/kg/day) improved sleep and behavior in 95% of the children, significantly increasing total sleep time by 72%, decreasing the number of awakenings by 76%, and reducing rage attacks by 33%.
Children with OMS exhibited multiple types of sleep disturbances, which contributed to rage attacks. Trazodone was effective in improving sleep and decreasing rage attacks and was well tolerated, even in toddlers.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16182678</pmid><doi>10.1016/j.jpeds.2005.05.016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 2005-09, Vol.147 (3), p.372-378 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68607574 |
| source | ScienceDirect Journals |
| subjects | Adolescent Affective Symptoms - drug therapy Affective Symptoms - etiology Biological and medical sciences Child Child, Preschool Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Dose-Response Relationship, Drug Female General aspects Humans Infant Male Medical sciences Nervous system (semeiology, syndromes) Neurology Oculomotor disorders Ophthalmology Paraneoplastic Syndromes, Nervous System - psychology Rage Retrospective Studies Serotonin Uptake Inhibitors - therapeutic use Sleep Wake Disorders - drug therapy Sleep Wake Disorders - etiology Trazodone - administration & dosage Trazodone - therapeutic use Treatment Outcome |
| title | Sleep Disturbance and Rage Attacks in Opsoclonus-Myoclonus Syndrome: Response to Trazodone |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T16%3A25%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sleep%20Disturbance%20and%20Rage%20Attacks%20in%20Opsoclonus-Myoclonus%20Syndrome:%20Response%20to%20Trazodone&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Pranzatelli,%20Michael%20R.&rft.date=2005-09-01&rft.volume=147&rft.issue=3&rft.spage=372&rft.epage=378&rft.pages=372-378&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/j.jpeds.2005.05.016&rft_dat=%3Cproquest_cross%3E68607574%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c432t-a1173a76245010159dc98d441c50cdfe1419b9a90012f108ee22a68ff6c656d93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68607574&rft_id=info:pmid/16182678&rfr_iscdi=true |