Adjuvant effect of Bacillus firmus in intranasal immunization of guinea pigs with inactivated type B infuenza virus

Intranasal immunization of guinea pigs with inactivated type B influenza virus plus inactivated Bacillus firmus as an adjuvant compared to the virus alone yields higher titers of serum hemagglutination-inhibiting antibodies and virus-neutralizing antibodies. This phenomenon could be useful in standa...

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Bibliographic Details
Published in:Folia microbiologica 2006, Vol.51 (2), p.154-156
Main Authors: Havlícková, M, Prokesová, L, Zanvit, P, Tácner, J, Limberková, R
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Antibodies, Viral - analysis
Bacillus
Bacillus - immunology
Bacillus firmus
Guinea Pigs
Influenza B virus - immunology
Influenza Vaccines - immunology
Influenza virus
Serologic Tests - methods
Vaccination - methods
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Summary:Intranasal immunization of guinea pigs with inactivated type B influenza virus plus inactivated Bacillus firmus as an adjuvant compared to the virus alone yields higher titers of serum hemagglutination-inhibiting antibodies and virus-neutralizing antibodies. This phenomenon could be useful in standard serology, especially in the preparation of immune sera against highly pathogenic strains for in vitro diagnosis.
ISSN:0015-5632
DOI:10.1007/BF02932172