Molecular Basis for Action of Bioactive Glasses as Bone Graft Substitute

Bone grafting procedures are undergoing a major shift from autologous and allogeneic bone grafts to synthetic bone graft substitutes. Bioactive glasses are a group of synthetic silica-based bioactive materials with bone bonding properties first discovered by Larry Hench. They have several unique pro...

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Bibliographic Details
Published in:Scandinavian journal of surgery 2006-01, Vol.95 (2), p.95-102
Main Authors: Välimäki, V.-V., Aro, H. T.
Format: Article
Language:English
Subjects:
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
Bone and Bones - metabolism
Bone Diseases - therapy
Bone Substitutes - pharmacology
Bone Substitutes - therapeutic use
Ceramics - pharmacology
Ceramics - therapeutic use
Fractures, Bone - therapy
Humans
Osseointegration - drug effects
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Summary:Bone grafting procedures are undergoing a major shift from autologous and allogeneic bone grafts to synthetic bone graft substitutes. Bioactive glasses are a group of synthetic silica-based bioactive materials with bone bonding properties first discovered by Larry Hench. They have several unique properties compared with other synthetic bioresorbable bioactive ceramics, such as calcium phosphates, hydroxyapatite (HA) and tricalcium phosphate (TCP). Bioactive glasses have different rates of bioactivity and resorption rates depending on their chemical compositions. The critical feature for the rate of bioactivity is a SiO2 content
ISSN:1457-4969
1799-7267
DOI:10.1177/145749690609500204