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Exercise training protects the renal circulation against high glucose challenge
It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined...
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| Published in: | Fundamental & clinical pharmacology 2005-10, Vol.19 (5), p.537-543 |
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| container_end_page | 543 |
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| container_title | Fundamental & clinical pharmacology |
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| creator | De Moraes, Roger Gioseffi, Giovanni Lopes, Nuno do Nascimento Gomes, Marilia Brito Nóbrega, Antonio Claudio Lucas Tibiriçá, Eduardo |
| description | It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12‐week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs–Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d‐glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose‐related vasodilator responses, reaching the maximum of 41 ± 2% (n = 10; P |
| doi_str_mv | 10.1111/j.1472-8206.2005.00358.x |
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This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12‐week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs–Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d‐glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose‐related vasodilator responses, reaching the maximum of 41 ± 2% (n = 10; P < 0.05). In the kidneys perfused with high concentrations of glucose (SED 15), endothelium‐dependent vasodilation was significantly blunted. Maximal relaxation in the presence of 15 mm glucose was of 19 ± 2%, which was significantly different from the SED 5.5 group (41 ± 2%, n = 10, P < 0.01). In the ExT 5.5 group, ACh‐induced vasodilation was significantly enhanced when compared with the SED 5.5 group, reaching the maximum of (52 ± 2%, n = 10, P < 0.05). Moreover, the exposure of the renal circulation of ExT animals to high glucose did not change endothelium‐dependent vasodilation induced by ACh (46 ± 3%, n = 6), when compared with the ExT 5.5 group. Finally, exercise training prevented the deleterious effects of high glucose on endothelial‐dependent renal vasodilation (SED 15: 19 ± 2% vs. ExT 15: 46 ± 3%; P < 0.05). It is concluded that exercise training protects the rabbit renal circulation against endothelial dysfunction elicited by acute exposure to moderately elevated glucose levels, corresponding to the postprandial glycemia of diabetes type 2 patients under treatment. The enhanced renal vasodilator reserve elicited by exercise training turns out to be a response that protects the kidney from the deleterious effects of glycemic peaks.</description><identifier>ISSN: 0767-3981</identifier><identifier>EISSN: 1472-8206</identifier><identifier>DOI: 10.1111/j.1472-8206.2005.00358.x</identifier><identifier>PMID: 16176332</identifier><identifier>CODEN: FCPHEZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; Biological and medical sciences ; diabetes mellitus ; Diabetes. Impaired glucose tolerance ; Dose-Response Relationship, Drug ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - physiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise Test - methods ; Female ; Glucose - administration & dosage ; Glucose - pharmacology ; hyperglycemia ; In Vitro Techniques ; Injections, Intravenous ; isolated rabbit kidney ; Kidney - blood supply ; Kidney - drug effects ; Kidney - physiology ; Male ; Medical sciences ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiology ; Pharmacology. Drug treatments ; Physical Conditioning, Animal - methods ; Physical Conditioning, Animal - physiology ; Rabbits ; Renal Circulation - drug effects ; Renal Circulation - physiology ; Time Factors ; vascular reactivity ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Fundamental & clinical pharmacology, 2005-10, Vol.19 (5), p.537-543</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4348-e4fb2b87a358b49fb425370568a4c1f4624039e5821fc5c4c5d6cc86d0c5e53b3</citedby><cites>FETCH-LOGICAL-c4348-e4fb2b87a358b49fb425370568a4c1f4624039e5821fc5c4c5d6cc86d0c5e53b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17087555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16176332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Moraes, Roger</creatorcontrib><creatorcontrib>Gioseffi, Giovanni</creatorcontrib><creatorcontrib>Lopes, Nuno do Nascimento</creatorcontrib><creatorcontrib>Gomes, Marilia Brito</creatorcontrib><creatorcontrib>Nóbrega, Antonio Claudio Lucas</creatorcontrib><creatorcontrib>Tibiriçá, Eduardo</creatorcontrib><title>Exercise training protects the renal circulation against high glucose challenge</title><title>Fundamental & clinical pharmacology</title><addtitle>Fundam Clin Pharmacol</addtitle><description>It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12‐week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs–Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d‐glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose‐related vasodilator responses, reaching the maximum of 41 ± 2% (n = 10; P < 0.05). In the kidneys perfused with high concentrations of glucose (SED 15), endothelium‐dependent vasodilation was significantly blunted. Maximal relaxation in the presence of 15 mm glucose was of 19 ± 2%, which was significantly different from the SED 5.5 group (41 ± 2%, n = 10, P < 0.01). In the ExT 5.5 group, ACh‐induced vasodilation was significantly enhanced when compared with the SED 5.5 group, reaching the maximum of (52 ± 2%, n = 10, P < 0.05). Moreover, the exposure of the renal circulation of ExT animals to high glucose did not change endothelium‐dependent vasodilation induced by ACh (46 ± 3%, n = 6), when compared with the ExT 5.5 group. Finally, exercise training prevented the deleterious effects of high glucose on endothelial‐dependent renal vasodilation (SED 15: 19 ± 2% vs. ExT 15: 46 ± 3%; P < 0.05). It is concluded that exercise training protects the rabbit renal circulation against endothelial dysfunction elicited by acute exposure to moderately elevated glucose levels, corresponding to the postprandial glycemia of diabetes type 2 patients under treatment. The enhanced renal vasodilator reserve elicited by exercise training turns out to be a response that protects the kidney from the deleterious effects of glycemic peaks.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>diabetes mellitus</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium, Vascular - physiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - pharmacology</subject><subject>hyperglycemia</subject><subject>In Vitro Techniques</subject><subject>Injections, Intravenous</subject><subject>isolated rabbit kidney</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Conditioning, Animal - methods</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rabbits</subject><subject>Renal Circulation - drug effects</subject><subject>Renal Circulation - physiology</subject><subject>Time Factors</subject><subject>vascular reactivity</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkM1qGzEUhUVoSdy0r1C0SXcz0b9kyKaYJA3kp5SWLoVGvjOWK8-k0gx13r5ybJJttJFA37n38CGEKalpOefrmgrNKsOIqhkhsiaES1Nvj9Ds5eMdmhGtdMXnhp6gDzmvCaGaUHWMTqiiWnHOZujhcgvJhwx4TC70oe_wYxpG8GPG4wpwgt5F7EPyU3RjGHrsusLlEa9Ct8JdnPxQwn7lYoS-g4_ofetihk-H-xT9urr8ufhW3T5c3yy-3lZecGEqEG3DGqNdqd2IedsIJrkmUhknPG2FYoLwOUjDaOulF14ulfdGLYmXIHnDT9GX_dzS9u8EebSbkD3E6HoYpmyVUbSM4wU0e9CnIecErX1MYePSk6XE7mTatd05sztndifTPsu02xL9fNgxNRtYvgYP9gpwdgBc9i62yfVF5SunidFSysJd7Ll_IcLTmwvYq8X38ijxah8PeYTtS9ylP1ZprqX9fX9tF0yTH3d3xt7z_xjfnq0</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>De Moraes, Roger</creator><creator>Gioseffi, Giovanni</creator><creator>Lopes, Nuno do Nascimento</creator><creator>Gomes, Marilia Brito</creator><creator>Nóbrega, Antonio Claudio Lucas</creator><creator>Tibiriçá, Eduardo</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Exercise training protects the renal circulation against high glucose challenge</title><author>De Moraes, Roger ; Gioseffi, Giovanni ; Lopes, Nuno do Nascimento ; Gomes, Marilia Brito ; Nóbrega, Antonio Claudio Lucas ; Tibiriçá, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4348-e4fb2b87a358b49fb425370568a4c1f4624039e5821fc5c4c5d6cc86d0c5e53b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>diabetes mellitus</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endothelium, Vascular - physiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - pharmacology</topic><topic>hyperglycemia</topic><topic>In Vitro Techniques</topic><topic>Injections, Intravenous</topic><topic>isolated rabbit kidney</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Conditioning, Animal - methods</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rabbits</topic><topic>Renal Circulation - drug effects</topic><topic>Renal Circulation - physiology</topic><topic>Time Factors</topic><topic>vascular reactivity</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Moraes, Roger</creatorcontrib><creatorcontrib>Gioseffi, Giovanni</creatorcontrib><creatorcontrib>Lopes, Nuno do Nascimento</creatorcontrib><creatorcontrib>Gomes, Marilia Brito</creatorcontrib><creatorcontrib>Nóbrega, Antonio Claudio Lucas</creatorcontrib><creatorcontrib>Tibiriçá, Eduardo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fundamental & clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Moraes, Roger</au><au>Gioseffi, Giovanni</au><au>Lopes, Nuno do Nascimento</au><au>Gomes, Marilia Brito</au><au>Nóbrega, Antonio Claudio Lucas</au><au>Tibiriçá, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise training protects the renal circulation against high glucose challenge</atitle><jtitle>Fundamental & clinical pharmacology</jtitle><addtitle>Fundam Clin Pharmacol</addtitle><date>2005-10</date><risdate>2005</risdate><volume>19</volume><issue>5</issue><spage>537</spage><epage>543</epage><pages>537-543</pages><issn>0767-3981</issn><eissn>1472-8206</eissn><coden>FCPHEZ</coden><abstract>It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12‐week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs–Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d‐glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose‐related vasodilator responses, reaching the maximum of 41 ± 2% (n = 10; P < 0.05). In the kidneys perfused with high concentrations of glucose (SED 15), endothelium‐dependent vasodilation was significantly blunted. Maximal relaxation in the presence of 15 mm glucose was of 19 ± 2%, which was significantly different from the SED 5.5 group (41 ± 2%, n = 10, P < 0.01). In the ExT 5.5 group, ACh‐induced vasodilation was significantly enhanced when compared with the SED 5.5 group, reaching the maximum of (52 ± 2%, n = 10, P < 0.05). Moreover, the exposure of the renal circulation of ExT animals to high glucose did not change endothelium‐dependent vasodilation induced by ACh (46 ± 3%, n = 6), when compared with the ExT 5.5 group. Finally, exercise training prevented the deleterious effects of high glucose on endothelial‐dependent renal vasodilation (SED 15: 19 ± 2% vs. ExT 15: 46 ± 3%; P < 0.05). It is concluded that exercise training protects the rabbit renal circulation against endothelial dysfunction elicited by acute exposure to moderately elevated glucose levels, corresponding to the postprandial glycemia of diabetes type 2 patients under treatment. The enhanced renal vasodilator reserve elicited by exercise training turns out to be a response that protects the kidney from the deleterious effects of glycemic peaks.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16176332</pmid><doi>10.1111/j.1472-8206.2005.00358.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetylcholine - pharmacology Animals Biological and medical sciences diabetes mellitus Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - physiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Test - methods Female Glucose - administration & dosage Glucose - pharmacology hyperglycemia In Vitro Techniques Injections, Intravenous isolated rabbit kidney Kidney - blood supply Kidney - drug effects Kidney - physiology Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Pharmacology. Drug treatments Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Rabbits Renal Circulation - drug effects Renal Circulation - physiology Time Factors vascular reactivity Vasodilation - drug effects Vasodilator Agents - pharmacology |
| title | Exercise training protects the renal circulation against high glucose challenge |
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