Glucocorticosteroids in allergic inflammation: clinical benefits in otitis media with effusion

Allergy and otitis media with effusion are often considered as comorbidities. Evidence points to a role for allergy in the pathogenesis of otitis media with effusion in reports of increased prevalence of allergy in patients with otitis media with effusion and presence of late-phase allergic-response...

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Bibliographic Details
Published in:Current allergy and asthma reports 2006-07, Vol.6 (4), p.327-333
Main Authors: Dhooge, Ingeborg, Verbruggen, Katia, Vandenbulcke, Liesbet
Format: Article
Language:English
Subjects:
Allergies
Anti-Asthmatic Agents - adverse effects
Anti-Asthmatic Agents - therapeutic use
Cytokines - metabolism
Ear diseases
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Hypersensitivity - complications
Hypersensitivity - drug therapy
Hypersensitivity - epidemiology
Hypersensitivity - metabolism
Inflammation - complications
Inflammation - drug therapy
Inflammation - epidemiology
Inflammation - metabolism
Medical disorders
Otitis Media with Effusion - complications
Otitis Media with Effusion - drug therapy
Otitis Media with Effusion - epidemiology
Otitis Media with Effusion - metabolism
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Summary:Allergy and otitis media with effusion are often considered as comorbidities. Evidence points to a role for allergy in the pathogenesis of otitis media with effusion in reports of increased prevalence of allergy in patients with otitis media with effusion and presence of late-phase allergic-response inflammatory mediators and cytokines in the middle-ear effusion of allergic subjects. However, the exact mechanism remains unknown. Many speculations have been made, but well-controlled studies to prove the efficacy of anti-allergic medication in the treatment of otitis media with effusion are lacking. Therefore, we do not recommend the use of glucocorticosteroids in allergic patients with otitis media with effusion.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-006-0068-6