Molecular properties of P2X receptors

P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or...

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Bibliographic Details
Published in:Pflügers Archiv 2006-08, Vol.452 (5), p.486-500
Main Authors: Roberts, Jonathan A, Vial, Catherine, Digby, Helen R, Agboh, Kelvin C, Wen, Hairuo, Atterbury-Thomas, Amelia, Evans, Richard J
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Amino Acid Sequence
Animals
Binding Sites
Humans
Ion Channel Gating - physiology
Mice
Models, Chemical
Models, Molecular
Molecular Sequence Data
Protein Binding
Proteins
Receptors, Purinergic P2 - chemistry
Receptors, Purinergic P2 - metabolism
Receptors, Purinergic P2X2
Structure-Activity Relationship
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Summary:P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range of phenotypes. This review aims to give an account of recent work on the molecular basis of the properties of P2X receptors. In particular, to consider emerging information on the assembly of P2X receptor subunits, channel regulation and desensitisation, targeting, the molecular basis of drug action and the functional contribution of P2X receptors to physiological processes.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-006-0073-6