Pseudo‐storage pool disease due to platelet degranulation in EDTA‐collected peripheral blood: a rare artifact

Summary We report a patient who was referred for acute myocardial infarction and presented a pseudo‐storage pool disease. The platelets from the blood collected with ethylene diamine tetra‐acetic acid (EDTA) were moderately underestimated by the automated analyser, stained poorly on the blood smear...

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Bibliographic Details
Published in:Clinical and laboratory haematology 2005-10, Vol.27 (5), p.336-342
Main Authors: LESESVE, J.‐F., LATGER‐CANNARD, V., LECOMPTE, T.
Format: Article
Language:English
Subjects:
Aged
Blood Platelets - pathology
Blood Specimen Collection - methods
Blood Specimen Collection - standards
Cell Degranulation - drug effects
Diagnostic Errors
Edetic Acid - pharmacology
ethylene diamine tetra‐acetic acid
Female
Histocytochemistry - standards
Humans
Myocardial Infarction - blood
Platelet
Platelet Count
Platelet Storage Pool Deficiency - diagnosis
pseudo‐grey platelet syndrome
pseudo‐storage pool disease
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Summary:Summary We report a patient who was referred for acute myocardial infarction and presented a pseudo‐storage pool disease. The platelets from the blood collected with ethylene diamine tetra‐acetic acid (EDTA) were moderately underestimated by the automated analyser, stained poorly on the blood smear and appeared agranular under the microscope. This artifactual anomaly does not occur in samples anticoagulated with citrate, heparin or the mixture citrate theophyline adenine dipyridamole. Reports of EDTA‐induced pseudo‐storage pool disease are scarce, possibly because underestimation of this poorly explained and difficult to diagnose phenomenon.
ISSN:0141-9854
1365-2257
DOI:10.1111/j.1365-2257.2005.00719.x