Palladium-Catalyzed Carbonylation of Yne Esters Leading to γ-Alkylidene α,β-Unsaturated γ-Lactones

The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.

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Bibliographic Details
Published in:Organic letters 2005-09, Vol.7 (20), p.4385-4387
Main Authors: Harada, Yasuyuki, Fukumoto, Yoshiya, Chatani, Naoto
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Catalysis
Esters - chemistry
Lactones - chemistry
Molecular Structure
Palladium - chemistry
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Description
Summary:The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0514956