Regulation of Mammalian Tooth Cusp Patterning by Ectodin

Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectod...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-09, Vol.309 (5743), p.2067-2070
Main Authors: Kassai, Yoshiaki, Munne, Pauliina, Hotta, Yuhei, Penttilä, Enni, Kavanagh, Kathryn, Ohbayashi, Norihiko, Takada, Shinji, Thesleff, Irma, Jernvall, Jukka, Itoh, Nobuyuki
Format: Article
Language:English
Subjects:
Animal teeth
Animals
Biological and medical sciences
Body Patterning
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins - biosynthesis
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - metabolism
Bone Morphogenetic Proteins - pharmacology
Bone Morphogenetic Proteins - physiology
Cell culture
Cell Cycle Proteins - biosynthesis
Cell Cycle Proteins - genetics
Cell Cycle Proteins - physiology
Chimera
Cyclin-Dependent Kinase Inhibitor p21
Dental anthropology
Dental Enamel - embryology
Dentistry
Dentition
Epithelium
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Genotype & phenotype
Hedgehog Proteins
Heterozygote
Individualized Instruction
Inhibition
Knots
Logical Thinking
Mammalia
Mathematical cusps
Mathematical Models
Mice
Mice, Inbred C57BL
Microscopy, Confocal
Molar - embryology
Molar - metabolism
Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus
Mutation
Odontogenesis
Organ Culture Techniques
Phenotypes
Physiological regulation
Rodents
Teeth
Tooth Crown - embryology
Tooth enamel
Trans-Activators - biosynthesis
Trans-Activators - genetics
Vertebrates: digestive system
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Description
Summary:Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1116848