Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers

Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence. Design: Cohort study with repeated measures. Setting: Clinical research center and emergency department at two academic medical centers. Participants: Seventy‐three subjects aged...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2005-10, Vol.53 (10), p.1761-1766
Main Authors: High, Kevin P., Trader, Melissa, Pahor, Marco, Loeb, Mark
Format: Article
Language:English
Subjects:
Acute Disease
Age Factors
Aged
Biological and medical sciences
CD16
CD28
CD28 Antigens - blood
CD8
CD8-Positive T-Lymphocytes - immunology
Chronic Disease
Chronic illnesses
Clinical outcomes
Community-Acquired Infections - immunology
Female
General aspects
Geriatric Assessment
Geriatrics
Humans
immune senescence
Immune system
Immunologic Factors - blood
Individuality
intraindividual variability
Lymphocyte Count
Male
Medical sciences
Neutrophils - immunology
Pneumonia, Bacterial - immunology
Receptors, IgG - blood
Reproducibility of Results
Statistics as Topic
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Summary:Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence. Design: Cohort study with repeated measures. Setting: Clinical research center and emergency department at two academic medical centers. Participants: Seventy‐three subjects aged 65 and older enrolled in three groups: chronic underlying conditions but no acute illness, acutely ill with infection (community‐acquired pneumonia), and acutely ill without infection. Measurements: CD16 density on polymorphonuclear neutrophils (PMNs) and the proportion of CD8+ T cells that express CD28 determined twice in the nonacutely ill group and three times (Days 0, 30, and 60) in the acute illness groups. Results: In the nonacutely ill group, PMN CD16 density demonstrated wide intraindividual variation, but there was a strong correlation for repeated measures of the percentage of CD8+ T cells expressing CD28 (correlation coefficient (r)=0.77, P
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2005.53526.x