Heterobifunctional Multivalent Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin

The first example of a multivalent heterofunctional inhibitor-adaptor, called “BAIT”, is described. This multivalent inhibitor-adaptor is able to capture a “target” receptor (Shiga toxin) through its recognition of one ligand of a heterobivalent headgroup while the other ligand binds to an endogenou...

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Published in:Organic letters 2005-09, Vol.7 (20), p.4369-4372
Main Authors: Solomon, Dmitry, Kitov, Pavel I, Paszkiewicz, Eugenia, Grant, Gordon A, Sadowska, Joanna M, Bundle, David R
Format: Article
Language:English
Subjects:
C-Reactive Protein - chemistry
C-Reactive Protein - metabolism
Glycosylation
Ligands
Molecular Structure
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - metabolism
Serum Amyloid P-Component - chemistry
Serum Amyloid P-Component - metabolism
Shiga Toxin - antagonists & inhibitors
Shiga Toxin - chemistry
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cited_by cdi_FETCH-LOGICAL-a310t-d645f833e08e791819d95a02962b3d19421293bfee5791403d7912c37585610c3
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container_issue 20
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creator Solomon, Dmitry
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description The first example of a multivalent heterofunctional inhibitor-adaptor, called “BAIT”, is described. This multivalent inhibitor-adaptor is able to capture a “target” receptor (Shiga toxin) through its recognition of one ligand of a heterobivalent headgroup while the other ligand binds to an endogenous “trap” protein (serum amyloid P component, SAP). BAIT showed markedly enhanced inhibition of toxin activity. An efficient synthesis of this multivalent cluster containing heterobifunctional ligands was accomplished by chemical and chemoenzymatic approaches.
doi_str_mv 10.1021/ol051529+
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects C-Reactive Protein - chemistry
C-Reactive Protein - metabolism
Glycosylation
Ligands
Molecular Structure
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - metabolism
Serum Amyloid P-Component - chemistry
Serum Amyloid P-Component - metabolism
Shiga Toxin - antagonists & inhibitors
Shiga Toxin - chemistry
title Heterobifunctional Multivalent Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin
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