Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that ou...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2005-07, Vol.10 (4), p.044010-0440110
Main Authors: Piao, Daqing, Sadeghi, Mehran M, Zhang, Jiasheng, Chen, Yueli, Sinusas, Albert J, Zhu, Quing
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis - diagnostic imaging
Atherosclerosis - pathology
biomedical optics
Calibration
Catheters, Indwelling
coherent optical systems
Disease Models, Animal
Equipment Design
Equipment Failure Analysis
Fluorodeoxyglucose F18
Image Enhancement - instrumentation
Image Enhancement - methods
imaging systems
Positron-Emission Tomography - instrumentation
Positron-Emission Tomography - methods
Rabbits
radiation
Radionuclide Imaging - instrumentation
Radionuclide Imaging - methods
Radiopharmaceuticals
Subtraction Technique - instrumentation
Systems Integration
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
Tomography, Optical Coherence - standards
Transducers
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Summary:We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.1954773