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Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models
We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that ou...
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| Published in: | Journal of Biomedical Optics 2005-07, Vol.10 (4), p.044010-0440110 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c423t-c8ac68ef8e2939e6cfbf437755ed4dc0e36edb987e0b356318d6adc5a86b7f873 |
| container_end_page | 0440110 |
| container_issue | 4 |
| container_start_page | 044010 |
| container_title | Journal of Biomedical Optics |
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| creator | Piao, Daqing Sadeghi, Mehran M Zhang, Jiasheng Chen, Yueli Sinusas, Albert J Zhu, Quing |
| description | We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with
positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection. |
| doi_str_mv | 10.1117/1.1954773 |
| format | article |
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Sadeghi, Mehran M ; Zhang, Jiasheng ; Chen, Yueli ; Sinusas, Albert J ; Zhu, Quing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-c8ac68ef8e2939e6cfbf437755ed4dc0e36edb987e0b356318d6adc5a86b7f873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - pathology</topic><topic>biomedical optics</topic><topic>Calibration</topic><topic>Catheters, Indwelling</topic><topic>coherent optical systems</topic><topic>Disease Models, Animal</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Fluorodeoxyglucose F18</topic><topic>Image Enhancement - instrumentation</topic><topic>Image Enhancement - methods</topic><topic>imaging systems</topic><topic>Positron-Emission Tomography - instrumentation</topic><topic>Positron-Emission Tomography - methods</topic><topic>Rabbits</topic><topic>radiation</topic><topic>Radionuclide Imaging - instrumentation</topic><topic>Radionuclide Imaging - methods</topic><topic>Radiopharmaceuticals</topic><topic>Subtraction Technique - instrumentation</topic><topic>Systems Integration</topic><topic>Tomography, Optical Coherence - instrumentation</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Tomography, Optical Coherence - standards</topic><topic>Transducers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piao, Daqing</creatorcontrib><creatorcontrib>Sadeghi, Mehran M</creatorcontrib><creatorcontrib>Zhang, Jiasheng</creatorcontrib><creatorcontrib>Chen, Yueli</creatorcontrib><creatorcontrib>Sinusas, Albert J</creatorcontrib><creatorcontrib>Zhu, Quing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Biomedical Optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piao, Daqing</au><au>Sadeghi, Mehran M</au><au>Zhang, Jiasheng</au><au>Chen, Yueli</au><au>Sinusas, Albert J</au><au>Zhu, Quing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models</atitle><jtitle>Journal of Biomedical Optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>10</volume><issue>4</issue><spage>044010</spage><epage>0440110</epage><pages>044010-0440110</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><coden>JBOPFO</coden><abstract>We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with
positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.</abstract><cop>United States</cop><pmid>16178644</pmid><doi>10.1117/1.1954773</doi><tpages>396101</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Atherosclerosis - diagnostic imaging Atherosclerosis - pathology biomedical optics Calibration Catheters, Indwelling coherent optical systems Disease Models, Animal Equipment Design Equipment Failure Analysis Fluorodeoxyglucose F18 Image Enhancement - instrumentation Image Enhancement - methods imaging systems Positron-Emission Tomography - instrumentation Positron-Emission Tomography - methods Rabbits radiation Radionuclide Imaging - instrumentation Radionuclide Imaging - methods Radiopharmaceuticals Subtraction Technique - instrumentation Systems Integration Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods Tomography, Optical Coherence - standards Transducers |
| title | Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models |
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