Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography

We suitably adapt the design of a tissue-equivalent phantom used for photoacoustic imaging to construct phantoms for optical elastography. The elastography phantom we consider should have optical properties such as scattering coefficient, scattering anisotropy factor, and refractive index; mechanica...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2005-07, Vol.10 (4), p.044020-0440210
Main Authors: Devi, C. Usha, Vasu, R. M, Sood, A. K
Format: Article
Language:English
Subjects:
Animals
Breast - physiology
Elasticity
elastography
Equipment Design
Equipment Failure Analysis
Humans
medical imaging
optical elastography
Optics and Photonics - instrumentation
Phantoms, Imaging
Physical Stimulation - methods
Polyvinyls - chemistry
Polyvinyls - radiation effects
Stress, Mechanical
tissue-equivalent phantom
Ultrasonography, Mammary - instrumentation
Ultrasonography, Mammary - methods
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Summary:We suitably adapt the design of a tissue-equivalent phantom used for photoacoustic imaging to construct phantoms for optical elastography. The elastography phantom we consider should have optical properties such as scattering coefficient, scattering anisotropy factor, and refractive index; mechanical properties such as storage and loss modulus; and acoustic properties such as ultrasound velocity, attenuation coefficient, and acoustic impedance to match healthy and diseased tissues. The phantom is made of poly (vinyl alcohol) (PVA) and its mechanical, optical, and acoustic properties are tailored by physical cross-linking effected through subjecting a suitable mix of PVA stock and water to a number of freeze-thaw cycles and by varying the degree of hydrolysis in the PVA stock. The optical, mechanical, and acoustic properties of the samples prepared are measured by employing different techniques. The measured variations in the values of optical scattering coefficient, scattering anisotropy factor, and refractive index and storage modulus are found to be comparable to those in normal and diseased breast tissues. The acoustic properties such as sound speed, acoustic attenuation coefficient, and density are found to be close to the average values reported in the literature for normal breast tissue.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.2003833