Hypoxic/ischemic models in newborn piglet : Comparison of constant FiO2 versus variable FiO2 delivery

A comparison of a constant (continuous delivery of 4% FiO2) and a variable (initial 5% FiO2 with adjustments to induce low amplitude EEG (LAEEG) and hypotension) hypoxic/ischemic insult was performed to determine which insult was more effective in producing a consistent degree of survivable neuropat...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2006-07, Vol.1100 (1), p.110-117
Main Authors: TRACEY BJÖRKMAN, S, FOSTER, Kelley A, O'DRISCOLL, Stephanie M, HEALY, Geneuieue N, LINGWOOD, Barbara E, BURKE, Chris, COLDITZ, Paul B
Format: Article
Language:English
Subjects:
Aging - physiology
Anesthesia
Animals
Animals, Newborn
Biological and medical sciences
Blood Gas Analysis
Blood Pressure - physiology
Body Weight - physiology
Brain - pathology
Data Interpretation, Statistical
Electroencephalography - drug effects
Hypoxia-Ischemia, Brain - pathology
Medical sciences
Neurology
Oxygen - administration & dosage
Oxygen Consumption - physiology
Respiration, Artificial
Swine
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A comparison of a constant (continuous delivery of 4% FiO2) and a variable (initial 5% FiO2 with adjustments to induce low amplitude EEG (LAEEG) and hypotension) hypoxic/ischemic insult was performed to determine which insult was more effective in producing a consistent degree of survivable neuropathological damage in a newborn piglet model of perinatal asphyxia. We also examined which physiological responses contributed to this outcome. Thirty-nine 1-day-old piglets were subjected to either a constant hypoxic/ischemic insult of 30- to 37-min duration or a variable hypoxic/ischemic insult of 30-min low peak amplitude EEG (LAEEG
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2006.04.119