Building the mouse gastrula: signals, asymmetry and lineages

The mouse embryo is built by assembling the progenitors of various tissue types into a body plan. Early postimplantation development involves the establishment of anatomical asymmetries and regionalized gene expression in the conceptus, the specification of tissue lineages, and the coordination of c...

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Bibliographic Details
Published in:Current opinion in genetics & development 2006-08, Vol.16 (4), p.419-425
Main Authors: Tam, Patrick PL, Loebel, David AF, Tanaka, Satomi S
Format: Article
Language:English
Subjects:
Activins - physiology
Animals
Body Patterning - physiology
Cell Lineage
Cell Movement
Endoderm - cytology
Endoderm - physiology
Gastrula - physiology
Germ Cells - physiology
Membrane Proteins - physiology
Mice
Nodal Protein
Signal Transduction
Transforming Growth Factor beta - physiology
Wnt Proteins - physiology
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Summary:The mouse embryo is built by assembling the progenitors of various tissue types into a body plan. Early postimplantation development involves the establishment of anatomical asymmetries and regionalized gene expression in the conceptus, the specification of tissue lineages, and the coordination of cell movement for correct positioning of the lineage progenitors before and at gastrulation. Recent findings reveal that Wnt and Tgfβ signalling function is instrumental in delineating the anterior–posterior embryonic axis by defining the site of primitive streak formation and by directing the movement of the visceral endoderm. These signalling activities are also required for the specification of anterior and posterior fates of the epiblast cells and for the induction and navigation of the primordial germ cells.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2006.06.008