Aquaporin‐4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess

Brain abscess is associated with local vasogenic edema, which leads to increased intracranial pressure and significant morbidity. Aquaporin‐4 (AQP4) is a water channel expressed in astroglia at the blood–brain and brain–CSF barriers. To investigate the role of AQP4 in brain abscess‐associated edema,...

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Bibliographic Details
Published in:Journal of neurochemistry 2005-10, Vol.95 (1), p.254-262
Main Authors: Bloch, Orin, Papadopoulos, Marios C., Manley, Geoffrey T., Verkman, A. S.
Format: Article
Language:English
Subjects:
Animals
Aquaporin 4
Aquaporins - genetics
Aquaporins - metabolism
Astrocytes - pathology
Biochemistry
Biological and medical sciences
Body Water - metabolism
Brain Abscess - complications
Brain Abscess - metabolism
Brain Abscess - pathology
Brain Edema - etiology
Brain Edema - metabolism
Brain Edema - pathology
Brain Edema - physiopathology
Brain research
cerebral edema
Chromosome aberrations
Gene Deletion
Gliosis - pathology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Immunology
Intracranial Pressure
Medical genetics
Medical sciences
Mice
Mice, Knockout
Nervous system (semeiology, syndromes)
Neurology
Neuroprotective Agents - metabolism
Rodents
Staphylococcal Infections - complications
Staphylococcal Infections - metabolism
Staphylococcal Infections - pathology
vasogenic edema
Water
water channel
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Summary:Brain abscess is associated with local vasogenic edema, which leads to increased intracranial pressure and significant morbidity. Aquaporin‐4 (AQP4) is a water channel expressed in astroglia at the blood–brain and brain–CSF barriers. To investigate the role of AQP4 in brain abscess‐associated edema, live Staphylococcus aureus (105 colony‐forming units) was injected into the striatum to create a focal abscess. Wild‐type and AQP4‐deficient mice had comparable immune responses as measured by brain abscess volume (∼ 3.7 mm3 at 3 days), bacterial count and cytokine levels in brain homogenates. Blood–brain barrier permeability was increased comparably in both groups as assessed by extravasation of Evans blue dye. However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean ± SEM 27 ± 2 vs. 17 ± 2 mmHg; p 
ISSN:0022-3042
1471-4159
DOI:10.1111/j.1471-4159.2005.03362.x