High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand

Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/6...

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Bibliographic Details
Published in:Cancer letters 2006-08, Vol.239 (2), p.292-297
Main Authors: Sriuranpong, V., Chantranuwat, C., Huapai, N., Chalermchai, T., Leungtaweeboon, K., Lertsanguansinchai, P., Voravud, N., Mutirangura, A.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - genetics
Amino Acid Sequence
Base Sequence
EGFR
Exons
Gefitinib
Humans
Kinases
Lung cancer
Lung Neoplasms - genetics
Molecular Sequence Data
Mutation
Receptor, Epidermal Growth Factor - genetics
Sequence Homology, Amino Acid
Studies
Thailand
Tyrosine kinase inhibitor
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Summary:Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/61 (57.4%). We found 29/60 (48.3%) of exon 19 deletions, 5/54 (9.3%) of exon 21 point mutations, and 1/54 (1.9%) of double-mutation of both exons. The presence of these mutations was significantly associated with non-smoking habit. In summary, we report a strikingly high prevalence of mutation of EGFR in Thai lung adenocarcinoma, which may explain the high response rate to the treatment with TKI among Asian populations.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.08.029