Endocrine tumours of the gastrointestinal tract. Somatostatin receptors as tools for diagnosis and therapy: molecular aspects

Somatostatin is a neuropeptide that acts as an endogenous inhibitor of various cellular functions including endocrine and exocrine secretions and the proliferation of normal and tumour cells. Its action is mediated by a family of G-protein-coupled receptors (sst1-sst5) that are widely distributed in...

Full description

Saved in:
Bibliographic Details
Published in:Baillière's best practice & research. Clinical gastroenterology 2005-08, Vol.19 (4), p.535-551
Main Authors: Guillermet-Guibert, Julie, Lahlou, Hicham, Pyronnet, Stéphane, Bousquet, Corinne, Susini, Christiane
Format: Article
Language:English
Subjects:
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - metabolism
Gastrointestinal Neoplasms - therapy
Humans
Indium Radioisotopes
MAP Kinase Kinase 2 - physiology
Neovascularization, Physiologic - physiology
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - therapy
Receptors, Somatostatin - physiology
Signal Transduction - physiology
Somatostatin - analogs & derivatives
Vascular Endothelial Growth Factor A - physiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Somatostatin is a neuropeptide that acts as an endogenous inhibitor of various cellular functions including endocrine and exocrine secretions and the proliferation of normal and tumour cells. Its action is mediated by a family of G-protein-coupled receptors (sst1-sst5) that are widely distributed in normal and tumour cells. Gastroenteropancreatic endocrine tumours express multiple somatostatin receptors, sst2 being clearly predominant. These receptors represent the molecular basis for the clinical use of somatostatin analogues in the treatment of endocrine tumours and their in vivo localisation. This review covers current knowledge in somatostatin receptor biology and signalling.
ISSN:1521-6918